Targeting the endocannabinoid system in the amygdala kindling model of temporal lobe epilepsy in mice

“The endocannabinoid system can be considered as a putative target to affect ictogenesis as well as the generation of a hyperexcitable epileptic network… These data give first evidence that CB1-receptor activation might render a disease-modifying approach. Future studies are necessary that further analyze the role of CB1 receptors and to confirm the efficacy of CB1-receptor agonists in other models of chronic epilepsy.”

http://www.ncbi.nlm.nih.gov/pubmed/21627644