Anti-tumoral Action of Cannabinoids

“Delta9-Tetrahydrocannabinol, the main active component of marijuana… Here, we show that intratumoral administration of Delta9-tetrahydrocannabinol… induced a considerable regression of malignant gliomas… Cannabinoid treatment did not produce any substantial neurotoxic effect… cannabinoids signal apoptosis (cell death/suicide) by a pathway involving cannabinoid receptors… These results may provide the basis for a new therapeutic approach for the treatment of malignant gliomas.”

‎”Remarkably, cannabinoids kill glioma cells selectively and can protect non-transformed glial cells from death…”

http://www.ncbi.nlm.nih.gov/pubmed/10700234

CANNABINOIDS: POTENTIAL ANTICANCER AGENTS

The study by Manuel Guzmán of Madrid Spain found that cannabinoids, the active components of marijuana, inhibit tumor growth in laboratory animals. They do so by modulating key cell-signalling pathways, thereby inducing direct growth arrest and death of tumor cells, as well as by inhibiting the growth of blood vessels that supply the tumor.

http://americanmarijuana.org/Guzman-Cancer.pdf 

Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy

“Hepatocellular carcinoma (HCC) is the third cause of cancer-related death worldwide… few therapeutic options are available… we investigated the effects of cannabinoids–a novel family of potential anticancer agents–on the growth of HCC. We found that Δ(9)-tetrahydrocannabinol (Δ(9)-THC, the main active component of Cannabis sativa)… reduced the viability of the human HCC cell lines…cannabinoids were also able to inhibit tumor growth… Our findings may contribute to the design of new therapeutic strategies for the management of HCC.”

http://www.ncbi.nlm.nih.gov/pubmed/21475304

The endocannabinoid system in prostate cancer

“Accumulating evidence indicate that the endocannabinoid system is dysregulated in prostate cancer… Overexpression of several components of the endocannabinoid system correlate with prostate cancer grade and progression, potentially providing a new therapeutic target for prostate cancer… several cannabinoids exert antitumoral properties against prostate cancer, reducing xenograft prostate tumor growth, prostate cancer cell proliferation and cell migration… the therapeutic potential of cannabinoids against prostate cancer is very promising…”

http://www.ncbi.nlm.nih.gov/pubmed/21912423

Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action

“These studies have suggested a wide range of possible therapeutic effects of cannabidiol on several conditions, including Parkinson’s disease, Alzheimer’s disease, cerebral ischemia, diabetes, rheumatoid arthritis, other inflammatory diseases, nausea and cancer.”

http://www.medicalmarijuanainc.com/index.php/alzheimer-s-disease

Cannabis Science Receives New Photos and Positive Feedback from Patient Three and an Oncologist about his Severe Squamous Cell Carcinoma

April 11, 2012

“COLORADO SPRING, Colo.–(BUSINESS WIRE)–Cannabis Science, Inc. (OTCBB: CBIS.OB) a pioneering U.S. biotech company developing pharmaceutical cannabis (marijuana) products, is pleased to provide new photographs of the existing treatment for patient three who has a “worst case” of treatment resistant, Squamous Cell Carcinoma. Cannabis Science has received positive feedback from both the patient and his Oncologist. These photos show the progressive reduction of the tumor masses that has occurred within the months of treatment.”

http://www.cannabisscience.com/news-a-media/press-releases/285-cannabis-science-receives-new-photos-and-positive-feedback-from-patient-three-and-an-oncologist-about-his-severe-squamous-cell-carcinoma.html

Cannabis Science Reports Second Cancer Patient Receives Clean Biopsy Report Confirming the Biopsy is Free of Cancer Cells

“Cannabis Science, Inc. a pioneering U.S. biotech company developing pharmaceutical cannabis (marijuana) products is happy to report that patient #2, who had a Squamous cell carcinoma on her arm, has received her biopsy report. It confirms what was visually apparent from the photo-documentation on our website. Her biopsy was free of cancer cells and she will not need any surgical procedure. Nevertheless, the patient will continue with her self-administered topical application of extracts for a while longer to minimize any chance of any surviving cancer cells in areas beyond what was biopsied.”

More: http://www.tradershuddle.com/20120404422008/Press-Releases/cannabis-science-reports-second-cancer-patient-receives-clean-biopsy-report-confirming-the-biopsy-is-free-of-cancer-cells.html

Cannabis Science Reports Success For 4th Brand New Self-Administering Cancer Patient

February 2, 2012

“DENVER–(BUSINESS WIRE)– Cannabis Science, Inc. (OTCBB:CBIS.OB – News) a pioneering U.S. biotech company developing pharmaceutical cannabis (marijuana) products, is pleased to introduce a 4th cancer patient with basal cell carcinoma (skin cancer) on his left nostril, who is self-administering a topical cannabis extract and having noticeable results.”

http://www.cannabisscience.com/news-a-media/press-releases/264-cannabis-science-reports-success-for-4th-brand-new-self-administering-cancer-patient.html

Cannabis Science Presents Newest Photographs From 3rd Cancer Patient That Show Cancer Tumors Dying and Areas That Are Now Pain Free

January 30, 2012

“DENVER–(BUSINESS WIRE)– Cannabis Science, Inc. (OTCBB:CBIS.OB) a pioneering U.S. biotech company developing pharmaceutical cannabis (marijuana) products, is pleased to share new photographs from this cancer patient with severe squamous cell carcinoma. These pictures clearly show that this patient, with previously treatment-resistant tumors, continues to make obvious improvement. The tumors appear to be dying and then healing after treatment with cannabis-based extracts.”

http://www.cannabisscience.com/news-a-media/press-releases/262-cannabis-science-presents-newest-photographs-from-3rd-cancer-patient-that-show-cancer-tumors-dying-and-areas-that-are-now-pain-free.html

Cannabis Science Updates Second Medical Cannabis Cancer Patient Suffering from Squamous Cell Carcinoma Photo-documents Cannabis Extracts Killing Cancerous Tumor

“Cannabis Science, Inc. (OTCBB: CBIS) a pioneering U.S. biotech company developing pharmaceutical cannabis (marijuana) products, is very pleased to announce that the second patient suffering from basal cell carcinoma (skin cancer) has self-administered cannabis extracts that appear to have eradicated the cancer.”

“Currently it appears that the aforementioned patient will be able to avoid any surgical procedures such as, standard surgical excision (Mohs Surgery), and other various types of treatment for skin cancer, like chemotherapy, radiation, and cryosurgery, by using the cannabis extracts…”

More: http://www.drugs.com/clinical_trials/cannabis-science-updates-second-medical-cannabis-cancer-patient-suffering-squamous-cell-carcinoma-12967.html