Category Archives: Addiction

The Hypocretin/Orexin Receptor-1 as a Novel Target to Modulate Cannabinoid Reward.

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“Although there is a high prevalence of users who seek treatment for cannabis dependence, no accepted pharmacologic treatment is available to facilitate and maintain abstinence.

 The hypocretin/orexin system plays a critical role in drug addiction, but the potential participation of this system in the addictive properties of cannabinoids is unknown.

 We investigated…  studies were performed to evaluate dopamine extracellular levels in the nucleus accumbens after acute Δ9-tetrahydrocannabinol administration..

… role of Hcrtr-1 in the reinforcing and motivational properties of WIN55,212-2 (THC) was confirmed…

CONCLUSIONS:

These findings demonstrate that Hcrtr-1 modulates the reinforcing properties of cannabinoids, which could have a clear therapeutic interest.”

http://www.ncbi.nlm.nih.gov/pubmed/23896204

Hepatic Cannabinoid Receptor Type 1 Mediates Alcohol-Induced Regulation of Bile Acid Enzyme Genes Expression Via CREBH.

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“In this study, we have investigated the effect of alcohol exposure on hepatic bile acid homeostasis and elucidated the mediatory roles of Cb1r and Crebh in this process.

We found that alcohol exposure or Cb1r-agonist 2-AG treatment increases hepatic bile acid synthesis and serum ALT, AST levels in vivo along with significant increase in Crebh gene expression and activation.

 Alcohol exposure activated Cb1r, Crebh, and perturbed bile acid homeostasis…

 Overall, our study demonstrates a novel regulatory mechanism of hepatic bile acid metabolism by alcohol via Cb1r-mediated activation of Crebh, and suggests that targeting Crebh can be of therapeutic potential in ameliorating alcohol-induced perturbation of bile acid homeostasis.”

http://www.ncbi.nlm.nih.gov/pubmed/23894352

Palmitoylethanolamide: From endogenous cannabimimetic substance to innovative medicine for the treatment of cannabis dependence.

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“Palmitoylethanolamide (PEA) is a fatty acid amide showing some pharmacodynamic similarities with Δ9-tetrahydrocannabinol, the principal psychoactive compound present in the cannabis plant.

Like Δ9-tetrahydrocannabinol, PEA can produce a direct or indirect activation of cannabinoid receptors.

 Furthermore, it acts as an agonist at TRPV1 receptor.

The hypothesis is that PEA has anti-craving effects in cannabis dependent patients, is efficacious in the treatment of withdrawal symptoms, produces a reduction of cannabis consumption and is effective in the prevention of cannabis induced neurotoxicity and neuro-psychiatric disorders.”

http://www.ncbi.nlm.nih.gov/pubmed/23896215

Role of cannabinoid CB2 receptor in the reinforcing actions of ethanol.

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“This study examines the role of the cannabinoid CB2 receptor (CB2 r) on the vulnerability to ethanol consumption… These results suggest that deletion of the CB2 r gene increased preference for and vulnerability to ethanol consumption…

Future studies will determine the role of CB2 r as a target for the treatment of problems related with alcohol consumption.”

http://www.ncbi.nlm.nih.gov/pubmed/23855434

Medical Cannabis Use Doesn’t Adversely Impact Substance Abuse Treatment Outcomes, Study Says

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“The physician-supervised use of medical marijuana does not adversely affect the outcomes of individuals enrolled in substance abuse treatment programs, according to clinical trial data published last week in the Harm Reduction Journal.

An investigator at Humboldt State University in California assessed whether medical cannabis use was associated with negative outcomes in patients referred to a substance abuse treatment program.

The study reported that treatment outcomes for medically authorized cannabis users were comparable to those of subjects who were not supervised to use the drug.

“Cannabis use did not seem to compromise substance abuse treatment amongst the medical marijuana using group, who (based on these preliminary data) fared equal to or better than non-medical marijuana users in several important outcome categories (e.g., treatment completion, criminal justice involvement, medical concerns),” the study concluded. “This exploratory study suggests that medical marijuana … may not adversely affect positive treatment outcomes.””

http://norml.org/news/2010/03/19/medical-cannabis-use-doesn-t-adversely-impact-substance-abuse-treatment-outcomes-study-says

“Medical marijuana users in substance abuse treatment” Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848643/

Marijuana Derivative May Offer Hope in Cocaine Addiction – TIME

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“A new study in mice has found that activating a receptor affected by marijuana can dramatically reduce cocaine consumption. The research suggests that new anti-addiction drugs might be developed using synthetic versions of cannabidiol (CBD), the marijuana component that activates the receptor—or even by using the purified natural compound itself.

Researchers formerly believed that the receptor, known as CB2, was not found in the brain and that therefore CBD had no psychoactive effects. But a growing body of research suggests otherwise. After THC, CBD is the second most prevalent active compound in marijuana.”

More: http://healthland.time.com/2011/07/26/marijuana-derivative-may-offer-hope-in-cocaine-addiction/

Transient changes in the endocannabinoid system after acute and chronic ethanol exposure and abstinence in the rat: a combined PET and microdialysis study.

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“Recent biochemical and post-mortem evidence suggests involvement of the endocannabinoid system in alcohol drinking behaviour and dependence…

CONCLUSION:

This study provides in vivo evidence that acute ethanol consumption is associated with enhanced endocannabinoid signalling in the NAcc, indicated by an increased CB1R binding and AEA content. In addition, chronic ethanol exposure leads to regional dysfunctions in CB1R levels, involving the hippocampus and caudate-putamen that are reversible within 2 weeks in this animal model.”

http://www.ncbi.nlm.nih.gov/pubmed/23740372

Colombia’s controversial cure for coke addicts: Give them marijuana

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“Marijuana has long been accused of being a gateway to deadlier vices. But could cannabis be a swinging door that might also lead people away from hard drugs? That’s what this capital city is trying to find out.

In a controversial public health project, Bogota will supply marijuana to 300 addicts of bazuco, a cheap cocaine derivative that generates crack-like highs and is as addictive as heroin.

For the most desperate users, the cannabis cure may be the only way out.

“People accuse us of turning bazuco addicts into marijuana addicts but that’s an urban myth,” he said. “This program is about reducing personal harm and the risks to society.”

Authorities believe they might rescue some of the addicts by supplying them with quality controlled medical marijuana with a high THC content (the mind-altering component of marijuana), specifically selected to relieve the anxiety that comes with kicking bazuco.”

More: http://www.thestar.com/news/world/2013/06/03/colombias_controversial_cure_for_coke_addicts_give_them_marijuana.html

Dysregulation of Cannabinoid CB1 Receptor and Associated Signaling Networks in Brains of Cocaine Addicts and Cocaine-Treated Rodents.

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The endocannabinoid system is implicated in the neurobiology of cocaine addiction. This study evaluated the status of cannabinoid CB1 and CB2 receptors, the endocytic cycle of CB1 receptors, receptor regulatory kinases (GRK), and associated signaling (mTOR and p70S6K) in brain cortex of drug abusers and cocaine- and cannabinoid-treated rodents…

 In long-term cocaine addicts, mTOR and p70S6K activations were not altered when compared with controls, indicating that CB1 receptor signaling was dampened. The dysregulation of CB1 receptor, GRK2/3/5, and mTOR/p70S6K signaling by cocaine may contribute to alterations of neuroplasticity and/or neurotoxicity in brains of cocaine addicts.”

More: http://www.ncbi.nlm.nih.gov/pubmed/23727505

Study finds medical marijuana has no impact on teen drug abuse

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“A working paper published Monday (PDF) claims that, despite the insistence of numerous U.S. officials, legalizing medical marijuana had no distinguishable effect on teen drug abuse rates in the surrounding communities.”

Medical marijuana via Andre Blais / Shutterstock

 

 
“Drawing upon data from 13 states from 1993 – 2009, professors from Montana State University, the University of Oregon and the University of Colorado Denver found that medical marijuana actually had a negative impact on the consumption of cocaine, the use of which declined 1.9 percent in areas that had legalized medical marijuana. It had no statistically significant impact on teen marijuana use.”