Marijuana’s Active Ingredient Targets Deadly Brain Cancer – WebMD

“If results of a recent rat study hold true in human trials, marijuana could be the treatment of choice for patients with malignant glioma — an especially aggressive and often fatal form of brain cancer.

 No, rats haven’t started smoking pot. But when researchers injected tumorous animals with cannabinoids — the drug’s active ingredient — about a third of them went into remission, and another third lived significantly longer than untreated rats.

The findings appear in the March issue of the journal Nature Medicine

According to lead researcher Manuel Guzmán, PhD, his team’s previous studies showed that cannabinoids could stop growth and kill cancer cells but did not harm normal cells. The current work examined the action behind this effect and whether it would also work in living animals…

The researchers first caused tumors in the brains of 18 rats. They then injected the animals over the course of seven days with either a natural or artificial cannabinoid, or a placebo for comparison. Additional groups of healthy, tumor-free rats also received the various treatments…

All of the untreated animals with tumors died between days 12 and 18, but those treated with the cannabinoids lived much longer, and had significantly smaller tumors…

There were no negative side effects at all in the healthy animals receiving treatment.”

More:http://www.webmd.com/cancer/news/20000228/marijuanas-active-ingredient-targets-deadly-brain-cancer

“Anti-tumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation” http://www.nature.com/nm/journal/v6/n3/abs/nm0300_313.html

Marijuana May Stall Brain Tumor Growth – WebMD

“Active Ingredient in Marijuana Inhibits Cancer Growth in Early Study.
 
The active ingredient in marijuana may help fight brain tumors, a new study suggests.
 

Researchers say the cannabinoids found in marijuana may aid in brain tumor treatment by targeting the genes needed for the tumors to sprout blood vessels and grow.

Their study showed that cannabinoids inhibited genes needed for the production of vascular growth factor (VEGF) in laboratory mice with glioma brain tumors and two patients with late-stage glioblastoma multiforme, a form of brain cancer.

VEGF is a protein that stimulates blood vessels to grow. Tumors need an abundant blood supply because they generally grow rapidly. So when VEGF is blocked, tumors starve from lack of blood supply and nutrients.

Blocking of VEGF constitutes one of the most promising tumor-fighting approaches currently available, says researcher Manuel Guzman, professor of biochemistry and molecular biology, at the Complutense University in Madrid, Spain, in a news release.”

More:http://www.webmd.com/cancer/news/20040815/marijuana-stall-brain-tumor-growth 

“Cannabinoids Inhibit the Vascular Endothelial Growth Factor Pathway in Gliomas”:  http://cancerres.aacrjournals.org/content/64/16/5617.long

 

Unhappy Couple
 

Link between obesity and cancer – Science

 

“Link between obesity and cancer” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670342/

“Biological mechanisms linking obesity and cancer risk: new perspectives.” http://www.ncbi.nlm.nih.gov/pubmed/19824817

“Overweight/obesity and cancer genesis: more than a biological link.” http://www.ncbi.nlm.nih.gov/pubmed/18035514

“The Obesity-Cancer Link: Lessons Learned from a Fatless Mouse” http://cancerres.aacrjournals.org/content/67/6/2391.long

“Epidemiology and pathophysiology of obesity as cause of cancer.” http://www.ncbi.nlm.nih.gov/pubmed/17299670

“Obesity and cancer.” http://www.ncbi.nlm.nih.gov/pubmed/19924603

“Obesity and cancer: pathophysiological and biological mechanisms.” http://www.ncbi.nlm.nih.gov/pubmed/18465361

“Obesity and cancer risk: evidence, mechanisms, and recommendations” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3476838/

 “The growing challenge of obesity and cancer: an inflammatory issue.” http://www.ncbi.nlm.nih.gov/pubmed/21793838

“Growth Signals, Inflammation, and Vascular Perturbations, Mechanistic Links Between Obesity, Metabolic Syndrome, and Cancer” http://atvb.ahajournals.org/content/32/8/1766.long

  “Obesity, metabolic dysregulation, and cancer: a growing concern and an inflammatory (and microenvironmental) issue” http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2012.06737.x/full

 “Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome.” http://www.ncbi.nlm.nih.gov/pubmed/23803760

“Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms” http://www.nature.com/nrc/journal/v4/n8/full/nrc1408.html

“Overweight and obesity: a review of their relationship to metabolic syndrome, cardiovascular disease, and cancer in South America.” http://www.ncbi.nlm.nih.gov/pubmed/23452284

“Cytokines, obesity, and cancer: new insights on mechanisms linking obesity to cancer risk and progression.” http://www.ncbi.nlm.nih.gov/pubmed/23121183

“Obesity-driven inflammation and cancer risk: role of myeloid derived suppressor cells and alternately activated macrophages” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555202/

“Inflammation, autophagy, and obesity: common features in the pathogenesis of pancreatitis and pancreatic cancer.” http://www.ncbi.nlm.nih.gov/pubmed/23622129

“Obesity, energy balance, and cancer: new opportunities for prevention.” http://www.ncbi.nlm.nih.gov/pubmed/23034147

 “Obesity and colorectal cancer.” http://www.ncbi.nlm.nih.gov/pubmed/23481261

“Obesity and Risk of Colorectal Cancer: A Meta-analysis of 31 Studies with 70,000 Events” http://cebp.aacrjournals.org/content/16/12/2533.long

 “Obesity and Risk of Colorectal Cancer: A Systematic Review of Prospective Studies” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547959/

 “Central obesity and breast cancer risk: a systematic review.” http://www.ncbi.nlm.nih.gov/pubmed/12916817

“Role of Obesity in the Risk of Breast Cancer: Lessons from Anthropometry” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575614/

“The molecular contribution of TNF-α in the link between obesity and breast cancer.” http://www.ncbi.nlm.nih.gov/pubmed/21165572

“Subcellular Localization of Cyclic AMP-Responsive Element Binding Protein-Regulated Transcription Coactivator 2 Provides a Link between Obesity and Breast Cancer in Postmenopausal Women” http://cancerres.aacrjournals.org/content/69/13/5392.long

 “An IL-6 link between obesity and cancer.” http://www.ncbi.nlm.nih.gov/pubmed/23277002

 “Expression of microRNAs: potential molecular link between obesity, diabetes and cancer.” http://www.ncbi.nlm.nih.gov/pubmed/21767342

“Excess body weight and obesity–the link with gastrointestinal and hepatobiliary cancer.” http://www.ncbi.nlm.nih.gov/pubmed/21386810

“Obesity and gastrointestinal cancer.” http://www.ncbi.nlm.nih.gov/pubmed/20306531

 “The link between obesity and prostate cancer: the leptin pathway and therapeutic perspectives.” http://www.ncbi.nlm.nih.gov/pubmed/16344847

“The relationship between obesity and prostate cancer: from genetics to disease treatment and prevention” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523022/

 “Reducing the weight of cancer: mechanistic targets for breaking the obesity-carcinogenesis link.” http://www.ncbi.nlm.nih.gov/pubmed/18971125

“Overweight, obesity, and cancer risk.” http://www.ncbi.nlm.nih.gov/pubmed/12217794

“Obesity and cancer: the risks, science, and potential management strategies.” http://www.ncbi.nlm.nih.gov/pubmed/16053036

 “Overweight as an avoidable cause of cancer in Europe.” http://www.ncbi.nlm.nih.gov/pubmed/11169969

“Obesity management–an opportunity for cancer prevention.” http://www.ncbi.nlm.nih.gov/pubmed/19848061

 

Scales

Study Links Obesity, Cancer – News

“Study Links Obesity, Cancer” http://www.cbsnews.com/video/watch/?id=3438650n

“‘Direct link’ between cancer and obesity” http://www.independent.co.uk/life-style/health-and-families/health-news/direct-link-between-cancer-and-obesity-398386.html

 “Obesity link to cancer” http://news.bbc.co.uk/2/hi/health/1334311.stm 

“Study supports link between obesity and higher incidence of cancer, poorer prognosis” http://medicalxpress.com/news/2012-10-link-obesity-higher-incidence-cancer.html

“Obesity-Cancer Link Detailed” http://www.the-scientist.com/?articles.view/articleNo/36204/title/Obesity-Cancer-Link-Detailed/

  “Obesity Linked to Many Cancer Cases in U.S.” http://www.webmd.com/cancer/news/20091105/obesity-linked-to-many-cancer-cases-in-us

“Increased obesity means increased cancer cases” http://thechart.blogs.cnn.com/2010/08/05/increased-obesity-means-increased-cancer-cases/

 “Obesity responsible for 100,000 cancer cases annually” http://edition.cnn.com/2009/HEALTH/11/05/obesity.cancer.link/

“Obesity is now the leading cause of cancer” http://www.nydailynews.com/life-style/health/obesity-leading-cancer-article-1.403496

“Obesity as a Cause of Endometrial Cancer: Gynecologic Oncologists to Add Perspective on New Report” http://www.newswise.com/articles/obesity-as-a-cause-of-endometrial-cancer-gynecologic-oncologists-to-add-perspective-on-new-report

“Obesity Helps Spur Cancer’s Growth, Mouse Study Suggests” http://healthyliving.msn.com/diseases/cancer/obesity-helps-spur-cancers-growth-mouse-study-suggests

“Obesity makes cancer harder to treat – researchers” http://abclocal.go.com/kabc/story?id=9167668

“Childhood Obesity linked to Colorectal Cancer” http://www.hivehealthmedia.com/childhood-obesity-linked-colorectal-cancer/

“Childhood obesity linked to bladder, urinary cancer” http://india.nydailynews.com/business/007bed187246683db27f00329afb7e2a/childhood-obesity-linked-to-bladder-urinary-cancer

“Study links childhood obesity to cancer in adults”  http://www.jpost.com/Health-and-Science/Study-links-childhood-obesity-to-cancer-in-adults 

 “Weight Gain and Obesity Linked with Endometrial Cancer Risk” http://news.yale.edu/2011/03/16/weight-gain-and-obesity-linked-endometrial-cancer-risk 

 “Athlone scientist reveals link between obesity and oesophageal cancer” http://www.westmeathindependent.ie/news/roundup/articles/2013/07/03/4016553-athlone-scientist-reveals-link-between-obesity-and-oesophageal-cancer/

“Scientists uncover key mechanism that links obesity and diabetes with cancer” http://www.news-medical.net/news/20130201/Scientists-uncover-key-mechanism-that-links-obesity-and-diabetes-with-cancer.aspx

 “Obesity Gene Linked To Skin Cancer” http://www.medicalnewstoday.com/articles/257159.php

“Obesity linked to liver cancer, gallbladder cancer” http://www.foodconsumer.org/newsite/Non-food/Disease/obesity_liver_cancer_gallbladder_cancer_0917120712.html

“Obesity linked to womb cancer rise” http://www.nursingtimes.net/nursing-practice/clinical-zones/public-health/obesity-linked-to-womb-cancer-rise/5017506.article

“Obesity Linked to Ovarian Cancer” http://abcnews.go.com/Health/Healthday/story?id=6581157&page=1

“Obesity genes linked to uterine cancer” http://news.vanderbilt.edu/2012/01/obesity-uterine-cancer/

 “Obesity Linked to Ovarian Cancer” http://articles.washingtonpost.com/2009-01-05/news/36784799_1_ovarian-cancer-obese-women-normal-weight-women

“Obesity Linked to More Advanced and More Aggressive Thyroid Cancer” http://www.familypracticenews.com/news/more-top-news/single-view/obesity-linked-to-more-advanced-and-more-aggressive-thyroid-cancer/30971304ec4a03ee4ce8abd728da736c.html

“Obesity Linked to Higher Risk for Aggressive Thyroid Cancer” http://www.medscape.com/viewarticle/764234

 “Pancreatic cancer and obesity linked” http://latimesblogs.latimes.com/booster_shots/2009/06/pancreatic-cancer-and-obesity-linked.html

 “Obesity linked to rise in kidney cancer” http://www.cancerresearchuk.org/cancer-info/news/archive/pressrelease/2002-09-21-obesity-linked-to-rise-in-kidney-cancer

 “Obesity fuels record rise in kidney cancers” http://www.nhs.uk/news/2012/03march/Pages/Obesity-fuels-kidney-cancer-rise.aspx

 “Obesity Linked to Prostate Cancer, Study Finds” http://www.webmd.com/prostate-cancer/news/20130423/obesity-linked-to-prostate-cancer-study-finds

“Obesity Raises Risk of Aggressive Prostate Cancer” http://www.renalandurologynews.com/obesity-raises-risk-of-aggressive-prostate-cancer/article/202883/#

 “Obesity increases men’s risk of dying from prostate cancer” http://www.nbcnews.com/health/obesity-increases-mens-risk-dying-prostate-cancer-6C9566874 

“Researchers discover link between obesity gene and breast cancer” http://medicalxpress.com/news/2011-05-link-obesity-gene-breast-cancer.html

 

 “Breast Cancer Linked to Obesity Gene, New Research Suggests” http://www.sciencedaily.com/releases/2011/05/110523124402.htm 

 

“Research Piles Up on Links Between Cancer and Obesity” http://blogs.wsj.com/health/2009/06/23/research-piles-up-on-links-between-cancer-and-obesity/

Cannabis Kills Cancer Cells

“Marijuana also found to prevent pain associated with chemotherapy”

Cannabis Kills Cancer Cells

“Studies in Spain have shown findings that Tetrahydrocannabinol (THC), the active ingredient found in marijuana, can induce the death of brain cancer cells, according to scientist Guillermo Velasco and his research team from the School of Biology at Complutense University in Madrid.

In a laboratory study where mice were “engineered” to carry three varying kinds of human cancer tumor grafts, THC was introduced into the brain, triggering a self-digestion development on a cellular level, known as “autophagy.” Within this process, the research team managed to isolate the particular activation route from which this process evolved.

The research team was also conducting clinical trials in concert, on two consenting brain cancer patients, said to be suffering from a rapidly aggressive form of cancer, known as “recurrent glioblastoma multiforme.”

The team, using electron microscopes to analyze brain tissue extracted before and after the 26 to 30-day regime, found that the THC had eradicated cancer cells, leaving the healthy cells undamaged.

The findings can now lend themselves to future design in newer cancer therapies, using the concept of autophagy activation.”

More: http://guardianlv.com/2013/08/cannabis-kills-cancer-cells/

THC is anticarcinogenic: marijuana may be cancer cure!

“Toxicology and Carcinogenesis Studies of 1-Trans-[Delta.sup.9]-Tetrahydrocannabinol

Summation of above:

“Thus, in our studies, rats and mice that received THC for 2 years exhibited body weight reductions, enhanced survival rates, and decreased tumor incidences in several sites, mainly organs under hormonal control. These earlier experimental carcinogenesis results on THC clearly lend further validity to the notion that cannabinoids may indeed be anticarcinogenic.””

 link
http://www.thefreelibrary.com/Antitumor+Effects+of+THC-a06814…

http://www.sodahead.com/united-states/thc-is-anticarcinogenic-marijuana-may-be-cancer-cure/question-1031413/?link=ibaf&q=THC+anti-carcinogenic+news

Dear Stoner: Can marijuana cure cancer?

“Yes, some parts of the cannabis plant have been shown to kill cancer cells in certain cases.” 

“Even if you don’t believe in any of that “hippie medicine” stuff, there’s been some actual scientific research done on cannabis and cancer, and a lot of it is promising. Spend a half-hour browsing around the National Center for Biotechnology Information website (ncbi.nlm.nih.gov) and you’ll find numerous studies on how various cannabinoids have been shown to slow or even kill tumor growth in everything from breast cancer to prostate cancer to skin cancer, thanks to our body’s natural endocannabinoids system.”

More: http://www.westword.com/2013-08-22/news/can-marijuana-cure-cancer/full/

The medical necessity for medicinal cannabis: prospective, observational study evaluating the treatment in cancer patients on supportive or palliative care.

“Cancer patients using cannabis report better influence from the plant extract than from synthetic products… We followed patients with a medicinal cannabis license to evaluate the advantages and side effects of using cannabis by cancer patients…

 All cancer or anticancer treatment-related symptoms showed significant improvement.

 No significant side effects except for memory lessening in patients with prolonged cannabis use were noted.

Conclusion. The positive effects of cannabis on various cancer-related symptoms are tempered by reliance on self-reporting for many of the variables. Although studies with a control group are missing, the improvement in symptoms should push the use of cannabis in palliative treatment of oncology patients.”

http://www.ncbi.nlm.nih.gov/pubmed/23956774

Full Text: http://www.hindawi.com/journals/ecam/2013/510392/

Study Links Aspartame To Cancer – News/Science

“Study Links Aspartame To Cancer” http://www.cbsnews.com/2100-500368_162-712605.html

 Controversial: The authority¿s view will be welcomed by manufacturers who use aspartame and similar sweeteners in fizzy drinks such as Diet Coke

“First Experimental Demonstration of the Multipotential Carcinogenic Effects of Aspartame Administered in the Feed to Sprague-Dawley Rats” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1392232/ 

“Aspartame administered in feed, beginning prenatally through life span, induces cancers of the liver and lung in male Swiss mice.” http://www.ncbi.nlm.nih.gov/pubmed/20886530 

“Life-Span Exposure to Low Doses of Aspartame Beginning during Prenatal Life Increases Cancer Effects in Rats” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1964906/

“Aspartame induces lymphomas and leukaemias in rats ” http://www.scribd.com/doc/74930468/Aspartame-induces-lymphomas-and-leukaemias-in-rats 

“Aspartame and Incidence of Brain Malignancies” http://cebp.aacrjournals.org/content/17/5/1295.long

“Aspartame bioassay findings portend human cancer hazards.” http://www.ncbi.nlm.nih.gov/pubmed/18085058 

“Sour Finding on Popular Sweetener: Increased Cancer Incidence Associated with Low-Dose Aspartame Intake” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1392271/

“Rat Study Shows Cancer, Aspartame Link” http://www.webmd.com/cancer/news/20051118/rat-study-shows-cancer-aspartame-link

 “Rat Study Shows Cancer, Aspartame Link” http://www.foxnews.com/story/0,2933,176258,00.html

“Aspartame Linked to Three Types of Cancer” http://www.foxnews.com/story/2007/06/28/aspartame-linked-to-three-types-cancer/

 “Study: Aspartame linked to blood cancers” http://www.digitaljournal.com/article/336384 

“Aspartame found to cause breast cancer, leukemia and lymphomas in latest animal experiments”  http://www.naturalnews.com/021920_aspartame_public_safety.html
 

 “Aspartame Causes Cancer in Rats at Levels Currently Approved for Humans” http://www.medicalnewstoday.com/releases/34040.php

“Aspartame linked to increased cancer risk in rats” http://www.nature.com/news/2005/051114/full/news051114-15.html 

Chocolate Fights Cancer – News/Science

“Dark Chocolate Fights Cancer”

http://cancerdirectory.com/cancer-nutrition/dark-chocolate-fights-cancer/

“Chocolate: food as medicine/medicine as food.” http://www.ncbi.nlm.nih.gov/pubmed/11603654

“Dark chocolate will help ward off pancreatic cancer”  http://www.nydailynews.com/life-style/health/dark-chocolate-ward-pancreatic-cancer-article-1.2484620

“Modulatory effects of polyphenols on apoptosis induction: relevance for cancer prevention.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635670/

“Effects of dark chocolate on azoxymethane-induced colonic aberrant crypt foci.” http://www.ncbi.nlm.nih.gov/pubmed/23859035

“Cancer protective properties of cocoa: a review of the epidemiologic evidence.” http://www.ncbi.nlm.nih.gov/pubmed/19838930

“Flavanols and procyanidins of cocoa and chocolate inhibit growth and polyamine biosynthesis of human colonic cancer cells.” http://www.ncbi.nlm.nih.gov/pubmed/11741742

“Potential for preventive effects of cocoa and cocoa polyphenols in cancer.” http://www.ncbi.nlm.nih.gov/pubmed/23439478

“In-vitro effects of polyphenols from cocoa and beta-sitosterol on the growth of human prostate cancer and normal cells.” http://www.ncbi.nlm.nih.gov/pubmed/16835506

“In Vitro and In Vivo Effects of Water Extract of White Cocoa Tea (Camellia ptilophylla) Against Human Prostate Cancer” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992824/

“Inhibitory effects of cocoa tea (Camellia ptilophylla) in human hepatocellular carcinoma HepG2 in vitro and in vivo through apoptosis.” http://www.ncbi.nlm.nih.gov/pubmed/22018604

“Chemopreventive effects of cocoa polyphenols on chronic diseases.” http://www.ncbi.nlm.nih.gov/pubmed/11682694

“Cocoa-rich diet prevents azoxymethane-induced colonic preneoplastic lesions in rats by restraining oxidative stress and cell proliferation and inducing apoptosis.” http://www.ncbi.nlm.nih.gov/pubmed/21953728

“Antitumor activity against murine lymphoma L5178Y model of proteins from cacao (Theobroma cacao L.) seeds in relation with in vitro antioxidant activity” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2974655/

“Protective activity of Theobroma cacao L. phenolic extract on AML12 and MLP29 liver cells by preventing apoptosis and inducing autophagy.” http://www.ncbi.nlm.nih.gov/pubmed/19883072

“Effect of cacao liquor extract on tumor marker enzymes during chemical hepatocarcinogenesis in rats.” http://www.ncbi.nlm.nih.gov/pubmed/15117546

“Pentameric procyanidin from Theobroma cacao selectively inhibits growth of human breast cancer cells.” http://mct.aacrjournals.org/content/4/4/537.long

“Chemoprevention of lung carcinogenesis by cacao liquor proanthocyanidins in a male rat multi-organ carcinogenesis model.” http://www.ncbi.nlm.nih.gov/pubmed/12609709

“Effects of cacao liquor proanthocyanidins on PhIP-induced mutagenesis in vitro, and in vivo mammary and pancreatic tumorigenesis in female Sprague-Dawley rats.” http://www.ncbi.nlm.nih.gov/pubmed/12169385

“Antimutagenesis and anticarcinogenesis, from the past to the future.” http://www.ncbi.nlm.nih.gov/pubmed/11506796

“Chronic toxicity/carcinogenicity studies of cocoa powder in rats.” http://www.ncbi.nlm.nih.gov/pubmed/1999308

“Cocoa Froths With Cancer-Preventing Compounds” http://www.sciencedaily.com/releases/2003/11/031119080419.htm

“Cancer-Fighting Organic Cocoa” http://www.organicauthority.com/blog/organic/cancer-fighting-organic-cocoa/

“Cocoa is loaded with anti-cancer phytochemicals and compounds, says research” http://www.naturalnews.com/000132.html

“Potential Role of Naturally Derived Polyphenols and Their Nanotechnology Delivery in Cancer.” http://www.ncbi.nlm.nih.gov/pubmed/23371307

“Natural polyphenols that display anticancer properties through inhibition of kinase activity.” http://www.ncbi.nlm.nih.gov/pubmed/20156174