Blood pressure regulation by endocannabinoids and their receptors

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“Cannabinoids and their endogenous and synthetic analogs exert powerful hypotensive and cardiodepressor effects by complex mechanisms involving direct and indirect effects on myocardium and vasculature.

On the one hand, endocannabinoids and cannabinoid receptors have been implicated in the hypotensive state associated with hemorrhagic, endotoxic and cardiogenic shock, and advanced liver cirrhosis.

On the other hand, there is emerging evidence suggesting that the endocannabinergic system plays an important role in the cardiovascular regulation in hypertension.

This review is aimed to discuss the in vivo hypotensive and cardiodepressant effects of cannabinoids mediated by cannabinoid and TRPV1 receptors, and focuses on the novel therapeutical strategies offered by targeting the endocannabinoid system in the treatment of hypertension.

The endocannabinergic system plays an important cardiovascular regulatory role not only in pathophysiological conditions associated with excessive hypotension but also in hypertension.

Thus, the pharmacological manipulation of this system may offer novel therapeutic approaches in a variety of cardiovascular disorders.”

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2225528/

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Cannabinoids for treatment of glaucoma.

“The purpose of this article is to review the current status of cannabis in the treatment of glaucoma, including the greater availability of marijuana in the USA.

The pharmacology of marijuana and its effect on intraocular pressure has not changed since the research in the 1970s and 1980s.

Marijuana is an effective ocular hypotensive agent.

However, cardiovascular and neurological effects are observed at the same dose, and may theoretically reduce the beneficial effect of lowering intraocular pressure by reducing ocular blood flow. The clinician must be cognizant of this potential in diagnosis, prognosis, and therapy.”

http://www.ncbi.nlm.nih.gov/pubmed/26840343

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Cannabis to lower blood pressure!

News Medical - Life Sciences & Medicine

“A new method for lowering blood pressure (hypertension) through use of a compound that synthesizes a cannabis (hashish) plant component has been developed by a pharmacology Ph.D. student at the Hebrew University of Jerusalem School of Pharmacy.

Cardiovascular disease (CVD) accounts for about one-third of all deaths in industrialized countries, and is the leading reason for visits there to physicians as well as for drug prescriptions. However, not all patients respond well to the drugs available. There is no “ideal’ hypotensive (blood pressure lowering) drug.

The cannabis plant – also known as hashish or marijuana – through its chemical compounds — cannabinoids — has been shown to have a beneficial, hypotensive effect.”

http://www.news-medical.net/news/2006/06/19/18517.aspx

Report shows relationship between sensation seeking, reward sensitivity and cannabis use

“Lowering Of Blood Pressure Achieved Through Use Of Hashish-like Drug”  http://www.sciencedaily.com/releases/2006/06/060620083025.htm

http://www.thctotalhealthcare.com/category/hypertension-high-blood-pressure/

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