Alcohol, Not Marijuana, A Gateway Drug

“While it may not settle the debate over how drug use begins, researchers found that alcohol, not marijuana, is the gateway drug that leads teens down the path of hard drug use, according to a new study that will be published in the August edition of the Journal of School Health.”

Marijuana

 

“”By recognizing the important predictive role of alcohol and delaying initiation of alcohol use, school officials and public health leaders can positively impact the progression of substance use,” Adam Barry, study author and an assistant professor at the University of Florida, said in a statement.”

Read more: http://www.isciencetimes.com/articles/3400/20120711/alcohol-marijuana-gateway-drug.htm

No ‘Smoking’ Gun: Research Indicates Teen Marijuana Use Does Not Predict Drug, Alcohol Abuse

“Marijuana is not a “gateway” drug that predicts or eventually leads to substance abuse, suggests a 12-year University of Pittsburgh study. Moreover, the study’s findings call into question the long-held belief that has shaped prevention efforts and governmental policy for six decades and caused many a parent to panic upon discovering a bag of pot in their child’s bedroom.

The Pitt researchers tracked 214 boys beginning at ages 10-12, all of whom eventually used either legal or illegal drugs. When the boys reached age 22, they were categorized into three groups: those who used only alcohol or tobacco, those who started with alcohol and tobacco and then used marijuana (gateway sequence) and those who used marijuana prior to alcohol or tobacco (reverse sequence).

Nearly a quarter of the study population who used both legal and illegal drugs at some point — 28 boys — exhibited the reverse pattern of using marijuana prior to alcohol or tobacco, and those individuals were no more likely to develop a substance use disorder than those who followed the traditional succession of alcohol and tobacco before illegal drugs, according to the study, which appears in this month’s issue of the American Journal of Psychiatry.

“The gateway progression may be the most common pattern, but it’s certainly not the only order of drug use,” said Ralph E. Tarter, Ph.D., professor of pharmaceutical sciences at the University of Pittsburgh School of Pharmacy and lead author of the study. “In fact, the reverse pattern is just as accurate for predicting who might be at risk for developing a drug dependence disorder.”

In addition to determining whether the gateway hypothesis was a better predictor of substance abuse than competing theories, the investigators sought to identify characteristics that distinguished users in the gateway sequence from those who took the reverse path. Out of the 35 variables they examined, only three emerged to be differentiating factors: Reverse pattern users were more likely to have lived in poor physical neighborhood environments, had more exposure to drugs in their neighborhoods and had less parental involvement as young children. Most importantly, a general inclination for deviance from sanctioned behaviors, which can become evident early in childhood, was strongly associated with all illicit drug use, whether it came in the gateway sequence, or the reverse.

While the gateway theory posits that each type of drug is associated with certain specific risk factors that cause the use of subsequent drugs, such as cigarettes or alcohol leading to marijuana, this study’s findings indicate that environmental aspects have stronger influence on which type of substance is used. That is, if it’s easier for a teen to get his hands on marijuana than beer, then he’ll be more likely to smoke pot. This evidence supports what’s known as the common liability model, an emerging theory that states the likelihood that someone will transition to the use of illegal drugs is determined not by the preceding use of a particular drug but instead by the user’s individual tendencies and environmental circumstances.

“The emphasis on the drugs themselves, rather than other, more important factors that shape a person’s behavior, has been detrimental to drug policy and prevention programs,” Dr. Tarter said. “To become more effective in our efforts to fight drug abuse, we should devote more attention to interventions that address these issues, particularly to parenting skills that shape the child’s behavior as well as peer and neighborhood environments.”

Indeed, according to the study, interventions focusing on behavior modification may be more effective prevention tactics than current anti-drug initiatives. For example, providing guidance to parents — particularly those in high-risk neighborhoods — on how to boost their caregiving skills and foster bonding with their children, could have a measurable effect on a child’s likelihood to smoke marijuana. Also, early identification of children who exhibit antisocial tendencies could allow for interventions before drug use even begins.

Although this research has significant implications for drug abuse prevention approaches, Dr. Tarter notes that the study has some limitations. First, as only male behaviors were studied, further investigation should explore if the results apply to women as well. Also, the examination of behaviors in phases beyond alcohol and marijuana consumption in the gateway series will be necessary.

Other study authors include Michael Vanyukov, Ph.D., and Maureen Reynolds, Ph.D., and Levent Kirisci, Ph.D., also of the University of Pittsburgh School of Pharmacy; and Duncan Clark, M.D., Ph.D., of the University of Pittsburgh School of Medicine. The research was funded by the National Institute on Drug Abuse.”

http://www.sciencedaily.com/releases/2006/12/061204123422.htm

STUDY SAYS MARIJUANA NO GATEWAY DRUG

“Marijuana is not a “gateway” drug that predicts or eventually leads to substance abuse, suggests a 12-year University of Pittsburgh study. Moreover, the study’s findings call into question the long-held belief that has shaped prevention efforts and governmental policy for six decades and caused many a parent to panic upon discovering a bag of pot in their child’s bedroom.”

Read more: http://scienceblog.com/12116/study-says-marijuana-no-gateway-drug/

Fighting Drug Addiction With Marijuana – ABC News

“For decades, Colombia has been searching for ways to treat people who are addicted to basuco, the nation’s version of crack cocaine. Now, the country’s capital, Bogota, is considering a new approach: transition users to marijuana.

BBC Mundo reports that the city is interested in trying a pilot program to see if pot helps mitigate the symptoms of withdrawal that basuco users experience. The goal is to minimize the social and health risks that accompany the drug.

Basuco isn’t the same as crack, but it’s an apt comparison. Like crack, it’s smokable and more common among a poorer segment of society.

When it comes to quality, basuco is some of the least pure cocaine out there. The base of the drug is an intermediary product that you get if you’re turning coca leaves into cocaine, and it can contain residue from the solvents used in that process, including kerosene. Dealers add things like ash and crushed bricks to give it bulk. For less than a dollar, you can get a short but powerful high.”

PHOTO: marijuana
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PHOTO: marijuana

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“The mayor’s office in Bogota is considering a pilot program that would look to transition drug addicts from hard drugs to marijuana.” 

“One expert in Bogota estimates that the city has at least 7,000 “problem users,” which means they might take up to 15-20 hits a day, according to BBC Mundo.

To confront the issue, the city is planning to test out “controlled consumption centers,” where addicts of hard drugs will be able to consume in a safer environment, with the goal of kicking the habit.

Julián Quintero, from the Bogota-based non-profit organization Acción Técnica Social, which works on drug policy, told BBC Mundo how such centers will work:

“The first thing you do is to start to reduce the dose. After that, you begin to change the way that it’s administered: if you were injecting heroin, you move to smoking heroin; after smoking heroin, you move to combining it with cannabis; after that, you’re staying with the cannabis,” he said. “What you’re looking for is for the person to reach a point where they can stabilize the consumption and that the consumption doesn’t prevent them from being functional.”

Is anyone in the U.S. trying this kind of approach to hard drugs?

No, according to Amanda Reiman, a policy manager with the Drug Policy Alliance, a group that favors alternatives to current drug laws.

“Unfortunately, universities rely on grants from the federal government for research, so most of what they do is what the feds want done,” she said in an email. “As you can probably guess, the feds are not too interested in beneficial uses for marijuana, and even less interested in how to help people who are addicted to substances, so most of the research in this area occurs outside the U.S. or through private funding.””

http://abcnews.go.com/ABC_Univision/News/fighting-drug-addiction-marijuana/story?id=18851710

AM404 attenuates reinstatement of nicotine seeking induced by nicotine-associated cues and nicotine priming but does not affect nicotine- and food-taking.

“Multiple studies suggest a pivotal role of the endocannabinoid system in the regulation of the reinforcing effects of various substances of abuse. Different approaches have been used to modulate endocannabinoid neurotransmission including the use of endogenous cannabinoid anandamide reuptake inhibitors.

 Previously, the effects of one of them, N-(4-hydroxyphenyl)-arachidonamide (AM404), have been explored in rodents trained to self-administer ethanol and heroin, producing some promising results. Moreover, AM404 attenuated the development and reinstatement of nicotine-induced conditioned place preference (CPP). In this study, we used the nicotine intravenous self-administration procedure to assess the effects of intraperitoneal administration of 0, 1, 3 and 10 mg/kg AM404 on nicotine-taking and food-taking behaviors under fixed-ratio and progressive-ratio schedules of reinforcement, as well as on reinstatement of nicotine-seeking induced by nicotine priming and by presentation of nicotine-associated cues. The ability of AM404 to produce place preference was also evaluated. AM404 did not produce CPP and did not modify nicotine-taking and food-taking behaviors. In contrast, AM404 dose-dependently attenuated reinstatement of nicotine-seeking behavior induced by both nicotine-associated cues and nicotine priming.

Our results indicate that AM404 could be a potential promising therapeutic option for the prevention of relapse to nicotine-seeking in abstinent smokers.”

http://www.ncbi.nlm.nih.gov/pubmed/23427192

Alcohol Not Marijuana Triggers Drug Abuse in Teenagers

“If you want your kids to stay away from drugs, then you might want to keep teenagers off alcohol because a new study says that long term drug abuse is likely to occur due to alcohol, not marijuana, use.

Researchers analyzed the data to find out what substances were being tried by students. They checked for use of marijuana, cocaine, heroin, LSD, amphetamines, tranquilizers and other narcotics.

Alcohol was the first substance to be tried by students, the results showed.

“By recognizing the important predictive role of alcohol and delaying initiation of alcohol use, school officials and public health leaders can positively impact the progression of substance use. I am confident in our findings and the clear implications they have for school-based prevention programs. By delaying and/or preventing the use of alcohol, these programs can indirectly reduce the rate of use of other substances,” Adam Barry, an assistant professor and researcher in the College of Health and Human Performance at the University of Florida.

“These findings add further credence to the literature identifying alcohol as the gateway drug to other substance use,” Barry said.”

Read more: http://www.medicaldaily.com/articles/10771/20120711/alcohol-addiction-marijuana-drugs.htm

Cannabinoid-1 receptor: a novel target for the treatment of neuropsychiatric disorders.

“G-protein-coupled receptor (GPCR)-mediated signalling is the most widely used signalling mechanism in cells, and its regulation is important for various physiological functions. The cannabinoid-1 (CB(1)) receptor, a GPCR, has been shown to play a critical role in neural circuitries mediating motivation, mood and emotional behaviours.

 Several recent studies have indicated that impairment of CB(1) receptor-mediated signalling may play a critical role in the pathophysiology of various neuropsychiatric disorders. In this article, the authors briefly review literature relating to the role played by the endocannabinoid system in various neuropsychiatric disorders, and the CB(1) receptor as a potential therapeutic target for the treatment of alcoholism, depression, anxiety and schizophrenia.”

http://www.ncbi.nlm.nih.gov/pubmed/16548770

Antagonism of cannabinoid 1 receptors reverses the anxiety-like behavior induced by central injections of corticotropin-releasing factor and cocaine withdrawal.

“The endocannabinoid (eCB) system is an important regulator of the stress response and mediates several stress-related behaviors, including anxiety. Despite anatomical evidence that eCBs interact with the principle stress peptide, corticotropin-releasing factor (CRF), few data exist that address functional interactions between these systems. Accordingly, we examined the effects of the CB1 receptor antagonist, AM251, on behavioral anxiety induced by (1) exogenous CRF, and (2) withdrawal from chronic cocaine exposure (mediated by CRF)… Our findings suggest that the anxiogenic effects of CRF and cocaine withdrawal are mediated, at least in part, by CB1 receptor transmission, and provide evidence in support of eCB-CRF interactions that are independent of the hypothalamic-pituitary-adrenal axis.”

http://www.ncbi.nlm.nih.gov/pubmed/21784132

From cannabis to the endocannabinoid system: refocussing attention on potential clinical benefits.

Image result for West Indian Med J

“Cannabis sativa is one of the oldest herbal remedies known to man. Over the past four thousand years, it has been used for the treatment of numerous diseases but due to its psychoactive properties, its current medicinal usage is highly restricted. In this review, we seek to highlight advances made over the last forty years in the understanding of the mechanisms responsible for the effects of cannabis on the human body and how these can potentially be utilized in clinical practice. During this time, the primary active ingredients in cannabis have been isolated, specific cannabinoid receptors have been discovered and at least five endogenous cannabinoid neurotransmitters (endocannabinoids) have been identified. Together, these form the framework of a complex endocannabinoid signalling system that has widespread distribution in the body and plays a role in regulating numerous physiological processes within the body. Cannabinoid ligands are therefore thought to display considerable therapeutic potential and the drive to develop compounds that can be targeted to specific neuronal systems at low enough doses so as to eliminate cognitive side effects remains the ‘holy grail’ of endocannabinoid research.”

http://www.ncbi.nlm.nih.gov/pubmed/23155985

Cannabis reinforcement and dependence: role of the cannabinoid CB1 receptor.

Abstract

“Awareness of cannabis dependence as a clinically relevant issue has grown in recent years. Clinical and laboratory studies demonstrate that chronic marijuana smokers can experience withdrawal symptoms upon cessation of marijuana smoking and have difficulty abstaining from marijuana use. This paper will review data implicating the cannabinoid CB1 receptor in regulating the behavioral effects of Δ9-tetrahydrocannobinol (THC), the primary psycho-active component of cannabis, across a range of species. The behavioral effects that will be discussed include those that directly contribute to the maintenance of chronic marijuana smoking, such as reward, subjective effects, and the positive and negative reinforcing effects of marijuana, THC and synthetic cannabinoids. The role of the CB1 receptor in the development of marijuana dependence and expression of withdrawal will also be discussed. Lastly, treatment options that may alleviate withdrawal symptoms and promote marijuana abstinence will be considered.”

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731704/