Phytochemical Aspects and Therapeutic Perspective of Cannabinoids in Cancer Treatment

Cannabis sativa L. – dried pistillate inflorescences and trichomes on their surface. (a) dried pistillate inflorescences (50% of the size); (b) non‐cystolithic trichome; (c) cystolithic trichome; (d) capitate‐sessile trichome; (e) simple bulbous trichome; (f) capitate‐stalked trichome (400×).

“Cannabis sativa L. (Cannabaceae) is one of the first plants cultivated by man and one of the oldest plant sources of fibre, food and remedies.

Cannabinoids comprise the plant‐derived compounds and their synthetic derivatives as well as endogenously produced lipophilic mediators. Phytocannabinoids are terpenophenolic secondary metabolites predominantly produced in CannabissativaL.

The principal active constituent is delta‐9‐tetrahydrocannabinol (THC), which binds to endocannabinoid receptors to exert its pharmacological activity, including psychoactive effect. The other important molecule of current interest is non‐psychotropic cannabidiol (CBD).

Since 1970s, phytocannabinoids have been known for their palliative effects on some cancer‐associated symptoms such as nausea and vomiting reduction, appetite stimulation and pain relief. More recently, these molecules have gained special attention for their role in cancer cell proliferation and death.

A large body of evidence suggests that cannabinoids affect multiple signalling pathways involved in the development of cancer, displaying an anti‐proliferative, proapoptotic, anti‐angiogenic and anti‐metastatic activity on a wide range of cell lines and animal models of cancer.”

https://www.intechopen.com/books/natural-products-and-cancer-drug-discovery/phytochemical-aspects-and-therapeutic-perspective-of-cannabinoids-in-cancer-treatment

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Antibacterial Properties of Hemp and Other Natural Fibre Plants: A Review

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“Intervention against pathogenic bacteria using natural plant material has a long history. Plant materials also have been widely used as fillers and/or reinforcers in polymer composites. Some natural fibre plants, such as hemp, are regarded to possess antibacterial activity against a wide range of pathogenic bacteria. Innovative applications can be explored if they are incorporated in polymer composites. This review aims to compile the relevant investigations on antibacterial activity of hemp and other fibre plants such as jute, flax, kenaf, sisal, and bamboo. The antibacterial character might be contributed from cannabinoids, alkaloids, other bioactive compounds, or phenolic compounds of lignin. This review is intended to encourage utilization of hemp and other natural fibre plants in value-added diversified products. Some potential applications are also discussed.” https://www.researchgate.net/publication/270502952_Antibacterial_Properties_of_Hemp_and_Other_Natural_Fibre_Plants_A_Review
“Antibacterial Properties of Hemp and Other Natural Fibre Plants: A Review”  http://ojs.cnr.ncsu.edu/index.php/BioRes/article/view/BioRes_09_2_Khan_Antibacterial_Hemp_Fibre_Review
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