Cannabinoids can inhibit tumor cell growth in highly invasive cancers

“A new study has found that Cannabinoids, the active components in marijuana, may aid in inhibiting tumor cell growth in highly invasive cancers.”

Fig. 4

“Although, Cannabinoids are used in reducing the side effects of cancer treatment, such as pain, weight loss, and vomiting, evidences indicate that they might even help in suppressing tumor invasion.

Robert Ramer, Ph.D., and Burkhard Hinz, Ph.D., of the University of Rostock in Germany investigated whether and by what mechanism cannabinoids hold back tumor cell invasion.

It was found that Cannabinoids did suppress tumor cell invasion and stimulated TIMP-1 expression.

TIMP-1 is an inhibitor of a group of enzymes involved in tumor cell invasion.

“To our knowledge, this is the first report of TIMP-1-dependent anti-invasive effects of cannabinoids,” the authors said.

They added: “This signaling pathway may play an important role in the antimetastatic action of cannabinoids, whose potential therapeutic benefit in the treatment of highly invasive cancers should be addressed in clinical trials.”

The study was published in the Journal of the National Cancer Institute (ANI)”

“Inhibition of Cancer Cell Invasion by Cannabinoids via Increased Expression of Tissue Inhibitor of Matrix Metalloproteinases-1” http://jnci.oxfordjournals.org/content/100/1/59.long

http://www.topnews.in/health/cannabinoids-can-inhibit-tumor-cell-growth-highly-invasive-cancers-2380 

Marijuana Ingredient Inhibits VEGF Pathway Required For Brain Tumor Blood Vessels

“Cannabinoids, the active ingredients in marijuana, restrict the sprouting of blood vessels to brain tumors by inhibiting the expression of genes needed for the production of vascular endothelial growth factor (VEGF).

“Blockade of the VEGF pathway constitutes one of the most promising antitumoral approaches currently available,” said Manuel Guzmán, professor of biochemistry and molecular biology, with the Complutense University in Madrid, Spain, and the study’s principal investigator.

“The present findings provide a novel pharmacological target for cannabinoid-based therapies.””

More: http://www.sciencedaily.com/releases/2004/08/040816085401.htm

“Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas.” http://cancerres.aacrjournals.org/content/64/16/5617.long

Anti-inflammatory activity of topical THC in DNFB-mediated mouse allergic contact dermatitis independent of CB1 and CB2 receptors.

“∆9 -Tetrahydrocannabinol (THC), the active constituent of Cannabis sativa, exerts its biological effects in part through the G-protein-coupled CB1 and CB2 receptors, which were initially discovered in brain and spleen tissue, respectively. However, THC also has CB1/2 receptor-independent effects. Because of its immune-inhibitory potential, THC and related cannabinoids are being considered for the treatment of inflammatory skin diseases.

Here we investigated the mechanism of the anti-inflammatory activity of THC and the role of CB1 and CB2 receptors…

CONCLUSIONS:

Topically applied THC can effectively attenuate contact allergic inflammation by decreasing keratinocyte-derived pro-inflammatory mediators that orchestrate myeloid immune cell infiltration independent of CB1/2 receptors.

This has important implications for the future development of strategies to harness cannabinoids for the treatment of inflammatory skin diseases.”

http://www.ncbi.nlm.nih.gov/pubmed/23889474

Marijuana cannabinoids found to help combat autism

cannabinoids

“(NaturalNews) The cannabinoid compounds naturally found in many varieties of cannabis, also known more commonly as marijuana, may help children with autism spectrum disorders experience dramatic behavioral improvements, and potentially even full recovery from their symptoms. These are the findings of a new study published in the journal Nature Communications that help reinforce the growing body of evidence which shows that medicinal cannabinoids hold incredible potential in both treating and potentially curing chronic illness…
 

Can non-psychoactive cannabinoid compounds actually cure chronic illness?

Though the researchers were quick to deny that cannabinoids hold any potential at actually curing autism, which more than likely was a politically-motivated denial rather than a factual admission, other research and actual case studies suggest that cannabinoid compounds are, indeed, powerful enough to mitigate many or all of the symptoms associated with autism, as well as many other diseases.”

 

Stanford University Study Finds That Marijuana Could Help With Autism

“A study conducted by Stanford University has found that there might be compounds in marijuana which have some very specific health benefits. The study’s results reveal that cannabinoids – which are found in cannabis – might help to treat autism.”

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“A new study shows that mutations associated with autism block the action of brain molecules that act on the same receptors that marijuana’s active chemical acts on,” according to the Autism Daily Newscast. “Thomas Sudhof, a cellular physiologist at Stanford University, tested mutations associated with autism in mice. Two mutations associated with autism in a synapse-adhesion protein led to deficits in prolonged endocannabinoid signaling in mice. This suggests that autism could caused by a disruption of the brain’s ability to send clear signals.
 
ADN references another study that supports the theory that cannabinoids could be used as a treatment to autism…”
 

More: http://www.opposingviews.com/i/health/stanford-university-study-finds-marijuana-could-help-autism#

Study Finds Cannabis May Provide Treatment For Autism

“A new study out of Standford University has found promising signs to suggest that cannabinoids – compounds found in cannabis, as well as naturally produced in our body – may help to treat autism.

According to Autism Daily Newscast (ADN); ”A new study shows that mutations associated with autism block the action of brain molecules that act on the same receptors that marijuana’s active chemical acts on”.

They continue: “Thomas Sudhof, a cellular physiologist at Stanford University, tested mutations associated with autism in mice. Two mutations associated with autism in a synapse-adhesion protein led to deficits in prolonged endocannabinoid signaling in mice. This suggests that autism could caused by a disruption of the brain’s ability to send clear signals”.

These findings suggest that cannabinoids could be used as a treatment to autism as they can unblock a disruption in the body’s cannabinoid receptors…”

More: http://www.theweedblog.com/study-finds-cannabis-may-provide-treatment-for-autism/

Hope for autistic children might lie in medical marijuana, study says – msn

Marijuana in a prescription bottle (© Gary Morrison/Getty Images)

“Stanford University released a study that will most likely add more fuel to the already contentious debate over medical marijuana, especially regarding its possible use by kids. The study, released in April, shows that cannabinoids, which are found in cannabis, might help treat autism. In the human brain, endocannabinoid signaling affects memory formation, learning, and other processes, but forms of autism can block these signals. When cannabinoids were present in the brains of mice being studied, these signals were able to get through. While more research is needed, autism groups are hopefull about the possibilties of medical marijuana. As the Autism Daily Newscast put it, “Many children with autism are already given cocktails of drugs that may be even stronger than marijuana, with serious side effects and limited results.”

http://now.msn.com/marijuana-affects-autism-by-helping-brain-signals-get-through-says-stanford-study

Medical Marijuana is Being Used to Successfully Treat the Symptoms of Lupus in Patients

“Cannabis is considered an ideal medication to help Lupus patients cope with the symptoms of the disorder like nausea and pain. It’s also known to be an anti-inflammatory, suppressing certain parts of the immune system.”

By lowering the levels of the inflammation-promoting protein interleukin-2, and raising levels of the anti-inflammatory protein interleukin-10, cannabis shows that it may be beneficial for treating autoimmune disorders where inflammation is the main complication.”

“There is no doubt that cannabis has some medicinal benefits, and helps patients to cope with symptoms of Lupus. On the contrary, medical cannabis is only legal in a number of states. The naturally grown “drug” remains illegal on a federal level, so one should consider the law and its consequences before deciding to self-medicate. Even if you live in a state where cannabis is legal medicinally, always consult your doctor before using cannabis to treat your condition.”

More Helpful Medical Marijuana & Lupus Resources:

  • http://www.mcsocal.com/blog/plaquenil-rheumatoid-arthritis-lupus-and-marijuana-cannabis
  • http://cure4lupus.org/store/index.php?main_page=page&id=164&chapter=1
  • http://www.thelupussite.com/
  • http://www.medicalnewstoday.com/info/lupus/
  • http://www.lupus.org/newsite/index.html
  • http://lupus.webmd.com/news/20030415/cannabis-may-suppress-immune-system
  • http://www.webmd.com/rheumatoid-arthritis/features/autoimmune-disease-and-ra
  • http://www.mayoclinic.com/health/lupus/DS00115/DSECTION=alternative-medicine

More: http://www.medicaljane.com/2013/01/07/lupus-and-medical-marijuana/

The pot diet

“Never mind the munchies, study finds that pot smokers weigh less than non-smokers.”

“Turns out that in spite of the late-night pizza binges and countless bags of Doritos they consume, the average marijuana user is actually less likely to be obese than the general, non-pot-smoking public.”

 More: http://healthyliving.msn.com/blogs/daily-apple-blog-post?post=5adb2a7c-1969-4a65-8554-1275f46faa94&_p=f178c720-63e5-4a6a-b939-6ba03f0bdc94

Health Benefits of Cannabis Tea

Health Benefits of Cannabis Tea 

 

“Reduces Chronic Pain

Reduces Anxiety

Reduces Nausea

May Treat Autoimmune Diseases”

“Marijuana-Infused Tea… Mom always said a cup of tea at night makes it easier to sleep.. Kevin Reed, of The Green Cross medical marijuana dispensary in San Francisco, advises patients to add a little milk after brewing to get the full effect of the cannabis.”  http://www.cbsnews.com/2300-204_162-10004358-12.html

 

“Cannabis Tea… Other names: Pot Tea, Weed Tea…Translations: Kaņepes Tēja, Kanapių arbata, Ceai de canabis, Kanabis Tea, Cần sa trà, Cannabis urządzenia, कैनबिस चाय, Chá de Cannabis, Каннабис чай, Η κάνναβη Τσάι, القنب الشاي, 대마초 차, Cannabis Čaj, Cannabis Teh, 大麻茶, Cannabis para preparar té, Cannabis Čaj, קנאביס תה, Канабис чај, 大麻コーヒー, Cannabis Te, Cannabis per a preparar te, Каннабіс чай, Kannabis Tea, Канабис чай”     http://www.foodista.com/food/3HJ8KNK6/cannabis-tea#

“Cannabis tea revisited: a systematic evaluation of the cannabinoid composition of cannabis tea.”   http://www.ncbi.nlm.nih.gov/pubmed/17604926

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