Category Archives: Cancer

Want Leukemia “awareness”? Please, BE AWARE:

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“Increase in rare childhood cancers linked to air pollution exposure” http://in.news.yahoo.com/increase-rare-childhood-cancers-linked-air-pollution-exposure-063414538.html
“Air Pollution and Childhood Cancer. A new study finds a link between air pollution exposure during pregnancy and childhood leukemia.”
http://health.yahoo.net/videos/healthday/air-pollution-and-childhood-cancer
“UCLA researchers find potential link between auto pollution, some childhood cancers” http://newsroom.ucla.edu/portal/ucla/ucla-researchers-link-auto-pollution-244911.aspx
“UCLA Researchers Find Potential Link Between Air Pollution And Childhood Cancer” http://losangeles.cbslocal.com/2013/04/09/ucla-researchers-find-potential-link-between-air-pollution-and-childhood-cancer/
“Leukemia, Other Pediatric Cancers Linked to Air Pollution”
http://www.empr.com/leukemia-other-pediatric-cancers-linked-to-air-pollution/article/288041/

“Air Pollution From Traffic Linked With Childhood Cancer” http://www.huffingtonpost.com/2013/04/09/air-pollution-traffic-childhood-cancer_n_3039048.html

“Leukemia, Other Pediatric Cancers Linked to Air Pollution” http://www.empr.com/leukemia-other-pediatric-cancers-linked-to-air-pollution/article/288041/

“NIH study finds childhood CT scans linked to leukemia and brain cancer later in life” http://nih.gov/news/health/jun2012/nci-07.htm
“NIH study finds childhood CT scans linked to leukemia and brain cancer later in life” http://www.cancer.gov/newscenter/newsfromnci/2012/CTpediatricLancet
“Childhood CT Scans Linked to Leukemia and Brain Cancer Later in Life” http://news.cancerconnect.com/childhood-ct-scans-linked-to-leukemia-and-brain-cancer-later-in-life/
“Childhood CT Scans Linked to Later Leukemia, Brain Cancer” http://www.medscape.com/viewarticle/765223

“Multiple CT scans in kids linked to later cancer risk” http://www.nbcnews.com/health/multiple-ct-scans-kids-linked-later-cancer-risk-6C10272110

“Link Between X-Rays And Increased Childhood Leukemia Risk”
http://www.medicalnewstoday.com/articles/203521.php
“X-rays can cause childhood leukemia”
http://www.naturalnews.com/029961_X-rays_leukemia.html

“X-Rays Linked to Increased Childhood Leukemia Risk” http://www.sciencedaily.com/releases/2010/10/101004101324.htm

“Survival at a Cost: Common Cancer Treatment Carries Huge Risks” http://abcnews.go.com/Health/radiation-therapy-linked-development-secondary-cancers-heart-disease/story?id=15864706

“Treatments linked to the development of second cancers”
http://www.cancer.org/cancer/cancercauses/othercarcinogens/medicaltreatments/secondcancerscausedbycancertreatment/second-cancers-caused-by-cancer-treatment-treatments-linked-to-second-cancers

“Decades Later, Chernobyl Accident Yields Clues to Leukemia Risk”
http://www.cancer.gov/ncicancerbulletin/111312/page5
“Exposure to low-level radiation can cause leukemia, U.S.-Ukraine study of Chernobyl cleanup workers finds” http://www.japantimes.co.jp/news/2012/11/09/national/exposure-to-low-level-radiation-can-cause-leukemia-u-s-ukraine-study-of-chernobyl-cleanup-workers-finds/
“Risk for Acute Myeloid Leukemia Linked to Chemotherapy”
http://www.medscape.com/viewarticle/779653
“Cancer Chemotherapy Tied to Slight Rise in Risk for Leukemia” http://www.drugs.com/news/cancer-chemotherapy-tied-slight-rise-risk-leukemia-43125.html
“Chemo Raises Leukemia Risk Slightly in Older Women”
http://www.breastcancer.org/research-news/20070924b
“Woops! Study Accidentally Finds Chemotherapy Makes Cancer Far Worse” http://naturalsociety.com/chemotherapy-makes-cancer-far-worse/
“Shock study: Chemotherapy can backfire, make cancer worse by triggering tumor growth” http://www.nydailynews.com/life-style/health/shock-study-chemotherapy-backfire-cancer-worse-triggering-tumor-growth-article-1.1129897
“Immunity Boosters Linked to Leukemia”
http://www.cbsnews.com/2100-500368_162-2441362.html
“Drugs That Boost Immunity During Cancer Chemo May Carry Leukemia Risk” http://www.webmd.com/breast-cancer/news/20070206/immunity-boosters-linked-leukemia
“Study: GMOs linked to leukemia and anemia”
http://www.digitaljournal.com/article/350126
“Agent Orange Linked to Childhood Cancer”
http://abcnews.go.com/Health/story?id=117503&page=1
“Agent Orange, Leukemia Linked”
http://www.cbsnews.com/2100-204_162-537775.html
“Insecticides: Potential Leukemia Risk. Study Examines Possible Link Between Head Lice Shampoo and Childhood Leukemia”
http://www.webmd.com/cancer/news/20060118/insecticides-potential-leukemia-risk
“Bug Spray Use Linked to Childhood Leukemia” http://www.medpagetoday.com/HematologyOncology/Leukemia/2503
“Fertility drugs linked to leukaemia”
http://news.uk.msn.com/uk/fertility-drugs-linked-to-leukaemia
“High blood sugar ups mortality in leukemia patients”
http://www.reuters.com/article/2007/08/30/us-high-blood-sugar-idUSKUA07460320070830
“NutraSweet Linked to Leukemia and Lymphoma”
http://www.naturalnews.com/026656_aspartame_leukemia_formaldehyde.html
“Sucralose Causes Cancer Concern” http://www.medicalnewstoday.com/articles/244603.php
“Splenda May Not Be So Splendid After All” http://news.yahoo.com/splenda-may-not-splendid-194239789.html
“Sweetener ‘linked’ to leukaemias” http://news.bbc.co.uk/2/hi/health/4683371.stm
“Diet Soft Drinks, Sodas can cause leukemia and lymphoma” http://www.agoracosmopolitan.com/news/headline_news/2012/11/02/4720.html
“Aspartame is linked to leukemia and lymphoma in new landmark study on humans” http://www.naturalnews.com/037772_aspartame_leukemia_lymphoma.html
“Doctors find link between obesity, leukemia” http://abclocal.go.com/kabc/story?id=7670509
“Obesity and Leukemia: Fat May Offer Sanctuary to Cancer Cells”
http://www.usnews.com/science/articles/2009/09/23/linking-obesity-with-leukemia-relapses
“Tea Ingredient Fights Leukemia. Lab Study: Green, Black, and Oolong Tea Boosts Immune Responses”
http://www.webmd.com/cancer/news/20050404/tea-ingredient-fights-leukemia

“Higher lymphoma risk for those living close to benzene-releasing sites, Georgia study finds” http://medcitynews.com/2013/07/higher-lymphoma-risk-for-those-living-close-to-benzene-releasing-sites-georgia-study-finds/

“Home distance from benzene sites linked to lymphoma risk”
http://www.nlm.nih.gov/medlineplus/news/fullstory_139158.html

“Benzene Exposure Linked to Increased Rate of NHL”
http://www.medscape.com/viewarticle/808573
“Samsung Chip Factory Causes Cancer, South Korea Government Finds” http://www.huffingtonpost.com/2012/12/14/samsung-chip-factory-cancer_n_2298294.html
“China’s Cancer-Causing Factories”
http://www.cbsnews.com/8301-18563_162-5237961.html
“Formaldehyde and Leukemia: Epidemiology, Potential Mechanisms and Implications for Risk Assessment” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839060/
“Formaldehyde Exposure among Industrial Workers Is Associated with Increased Risk of Cancers of the Blood and Lymphatic System” http://www.cancer.gov/newscenter/newsfromnci/2009/formaldehyde
“Hexavalent Chromium, Cancer-Causing Toxin, Common in Tap Water: What to Do” http://www.cbsnews.com/8301-504763_162-20026157-10391704.html
“Chromium in Drinking Water Causes Cancer”
http://www.scientificamerican.com/article.cfm?id=chromium-water-cancer
“Lack of vitamin D in patients with leukemia “ups death risk””
http://www.dailyindia.com/show/406851.php
“The Vitamin D and Cancer Connection: Research Shows the Link”
http://news.cancerconnect.com/the-vitamin-d-and-cancer-connection-research-shows-the-link/

“Insufficient Vitamin D Levels in Chronic Lymphocytic Leukemia Patients Linked to Cancer Progression and Death”
http://www.sciencedaily.com/releases/2010/11/101104094038.htm

“Mayo Clinic Finds Insufficient Vitamin D Levels in CLL Patients Linked to Cancer Progression and Death”
http://www.mayoclinic.org/news2010-rst/6033.html

Be aware:  http://www.thctotalhealthcare.com/category/leukemia/

 ferrando stock child

Cannabidiol (CBD) Shown To Kill Breast Cancer Cells

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 “Cannabidiol (CBD) has been on the receiving end of a lot of attention from the scientific community for several decades now. However, it is only now that we are really starting to begin to get a grasp on how wonderful this cannabinoid truly is.

 

A study from 2011 states that cannabidiol is considered an antineoplastic agent on the basis of its in vitro and in vivo activity against tumor cells. However, the exact molecular mechanism through which CBD works in this capacity is yet to be understood. The study, titled “Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-talk between Apoptosis and Autophagy,” focuses on how CBD can kill breast cancer cells. Breast cancer is the second leading cause of cancer-related death in women in the United States.

What the scientists found was that CBD influences apoptosis by interacting with a key protein, called beclin-1, found within the cancerous cell. Beclin-1 is also known to play a key role in autophagy, or cellular self-degradation of non-vital components, which may lead to programmed cell death. This causes a distortion of the electrical signals between the outer mitochondrial membrane and the rest of the cell, disrupting the transfer to the cell interior of certain molecules that are necessary for metabolism. What this means is that the cell cannot transfer energy, and the cell starves to death, and in doing so activates the self-destruction process of apoptosis.

The study concludes by stating, “In summary, we showed that CBD, a plant-derived cannabinoid, preferentially kills breast cancer cells by inducing ER stress, inhibiting mTOR signaling, enhancing ROS generation, and mediating a complex balance between autophagy and mitochondria-mediated apoptosis in MDA-MB-231 breast cancer cells. These findings support the continued exploration of CBD as an alternative agent for breast cancer treatment.””

http://cbdgum.networkofhemp.com/cannabidiol-cbd-shown-to-kill-breast-cancer-cells/

“Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-talk between Apoptosis and Autophagy… In summary, we showed that CBD, a plant-derived cannabinoid, preferentially kills breast cancer cells…” http://mct.aacrjournals.org/content/10/7/1161.full

THC Gives Cancer Cells the Munchies Too

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“…THC and other cannabinoids are actively being investigated for various useful clinical purposes, including the treatment of cancer through the inhibition of tumor growth.

A new study by Salazar et al. in The Journal of Clinical Investigation demonstrates that THC causes tumor cells to begin to degrade themselves from the inside (a process called autophagy, i.e. “self-eating”). Although autophagy has been shown to promote cell survival in some cases and cell death in others, the authors show that in this case it causes cancer cells to undergo programmed cell death (apoptosis). Thus, THC activates a series of events within cancer cells, inhibiting tumor growth.”

More: http://scienceblogs.com/scientificactivist/2009/04/02/thc-gives-cancer-cells-the-mun/

“Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673842/

Critical appraisal of the potential use of cannabinoids in cancer management

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“Cannabinoids have been attracting a great deal of interest as potential anticancer agents. Originally derived from the plant Cannabis sativa, there are now a number of endo-, phyto- and synthetic cannabinoids available. This review summarizes the key literature to date around the actions, antitumor activity, and mechanisms of action for this broad range of compounds…

Two therapeutic avenues exist for the development of cannabinoids as anticancer agents. As antiemetic and analgesic compounds, this class of compounds has been explored in terms of palliative care. More recently, cannabinoid agonists and antagonists have been screened for potential direct antitumorigenic properties.

… results suggest that overall the cannabinoids affect multiple cellular signaling pathways, which means they have the potential to decrease cancer development, growth, and metastasis.

Overall, the cannabinoids may show future promise in the treatment of cancer, but there are many significant hurdles to be overcome. There is much still to be learned about the action of the cannabinoids and the endocannabinoid system.

It is a distinct possibility that the cannabinoids may have a place in the future treatment of cancer.”

Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770515/

The CB2 cannabinoid receptor signals apoptosis via ceramide-dependent activation of the mitochondrial intrinsic pathway.

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“Delta9-tetrahydrocannabinol and other cannabinoids exert pro-apoptotic actions in tumor cells via the CB2 cannabinoid receptor…

 Here we used the human leukemia cell line Jurkat-that expresses CB2 as the unique CB receptor-to investigate…

 In summary, results presented here show that CB2 receptor activation signals apoptosis via a ceramide-dependent stimulation of the mitochondrial intrinsic pathway.”

http://www.ncbi.nlm.nih.gov/pubmed/16624285

Cannabinoid receptors expression in bone marrow trephine biopsy of chronic lymphocytic leukaemia patients treated with purine analogues.

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“Cannabinoid receptors CB1 and CB2 are part the endocannabinoid system that plays an important role in the process of proliferation and apoptosis of different neoplastic cells. B-cell chronic lymphocytic leukaemia is one of the diseases in which these processes are altered… The aim of our study was the assessment of cannabinoid receptor expression on the B-lymphocytes in bone marrow trephine biopsy from leukaemic patients at diagnosis and after purine analogue treatment….

CONCLUSION:

The study provides original evidence for the existence of cannabinoid receptors on B-lymphocytes in chronic lymphocytic leukaemia patients. The receptors are thought to be a new structure that can modify the course of the disease and may be considered as a new target in leukaemia treatment.”

http://www.ncbi.nlm.nih.gov/pubmed/18004250

Enhancing the in vitro cytotoxic activity of Delta9-tetrahydrocannabinol in leukemic cells through a combinatorial approach.

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“Delta(9)-Tetrahydrocannabinol (THC) is the active metabolite of cannabis, which has demonstrable cytotoxic activity in vitro. In support of our previously published data, we have investigated the interactions between THC and anti-leukemia therapies and studied the role of the signalling pathways in mediating these effects.

 Results showed clear synergistic interactions between THC and the cytotoxic agents in leukemic cells…

 Overall, these results demonstrate for the first time that a combination approach with THC and established cytotoxic agents may enhance cell death in vitro. Additionally the MAPK/ERK pathway appears responsible in part for these effects.”

http://www.ncbi.nlm.nih.gov/pubmed/18608861

Cannabidiol-Induced Apoptosis in Human Leukemia Cells: A Novel Role of Cannabidiol in the Regulation of p22phox and Nox4 Expression

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“Marijuana has been suggested as a potent therapeutic agent alleviating such complications as intraocular pressure in glaucoma and cachexia, nausea, and pain in AIDS and cancer patients. A number of recent studies now suggest the possible use of these compounds for the treatment of cannabinoid receptor-expressing tumors…

In the current study, we examined the effects of the nonpsychoactive cannabinoid, cannabidiol, on the induction of apoptosis in leukemia cells. Exposure of leukemia cells to cannabidiol led to cannabinoid receptor 2 (CB2)-mediated reduction in cell viability and induction in apoptosis. Furthermore, cannabidiol treatment led to a significant decrease in tumor burden and an increase in apoptotic tumors in vivo…

Together, the results from this study reveal that cannabidiol, acting through CB2 and regulation of Nox4 and p22phox expression, may be a novel and highly selective treatment for leukemia…

In summary, the current study demonstrates that CBD-induced apoptosis may constitute a novel approach to treat malignancies of the immune system…”

Full text: http://molpharm.aspetjournals.org/content/70/3/897.long

Cannabidiol, unlike synthetic cannabinoids, triggers activation of RBL-2H3 mast cells

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“Plant-derived cannabinoids, such as Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD), the main psychoactive and nonpsychoactive components of cannabis, respectively, possess myriad pharmacological properties…

Cannabidiol (CBD), a prominent psychoinactive component of cannabis with negligible affinity for known cannabinoid receptors, exerts numerous pharmacological actions, including anti-inflammatory and immunosuppressive effects…

Together, these results support existence of yet-to-be identified sites of interaction, i.e., receptors and/or ion channels associated with Ca2+ influx of natural cannabinoids such as CBD and THC, the identification of which has the potential to provide for novel strategies and agents of therapeutic interest.”

Full text: http://www.jleukbio.org/content/81/6/1512.long

Cannabinoids induce incomplete maturation of cultured human leukemia cells.

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“Monocyte maturation markers were induced in cultured human myeloblastic ML-2 leukemia cells after treatment for 1-6 days with 0.03-30 microM delta 9-tetrahydrocannabinol (THC), the major psychoactive component of marijuana…

 Cannabinoids induce incomplete maturation of cultured human leukemia cells…

Findings obtained from this system may have important implications for studies of cannabinoid effects on normal human bone-marrow progenitor cells.”

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC298868/