Category Archives: Cancer

Cannabidiol enhances the inhibitory effects of Δ9-tetrahydrocannabinol on human glioblastoma cell proliferation and survival

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Molecular Cancer Therapeutics

“Δ9-THC and other cannabinoids can act as direct anticancer agents in multiple types of cancer in culture and in vivo. 

Individually, Δ9-THC and CBD can activate distinct pathways in glioblastoma cells that ultimately culminate in inhibition of cancer cell growth and invasion as well as induction of cell death.

We hypothesized that, if the individual agents were combined, a convergence on shared pathways may ensue leading to an enhanced ability of the combination treatment to inhibit certain cancer cell phenotypes.

We found this to be true in this investigation.

CBD enhances the inhibitory effects of Δ9-THC on glioblastoma cell growth.

Cannabidiol significantly improved the inhibitory effects of Δ9-tetrahydrocannabinol on glioblastoma cell proliferation and survival.

The Combination Treatment of Δ9-THC and Cannabidiol Inhibits Cell Cycle and Induces Apoptosis.

Our results suggest that the addition of CBD to Δ9-THC may improve the overall effectiveness of Δ9-THC in the treatment of glioblastoma in cancer patients.”

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806496/

http://mct.aacrjournals.org/content/9/1/180.full

“CBD Enhances the Anticancer Effects of THC”  https://www.scribd.com/document/50154001/CBD-Enhances-the-Anticancer-Effects-of-THC-Journal-MCT-Marcu

Cannabinoids can inhibit tumor cell growth in highly invasive cancers

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“A new study has found that Cannabinoids, the active components in marijuana, may aid in inhibiting tumor cell growth in highly invasive cancers.”

Fig. 4

“Although, Cannabinoids are used in reducing the side effects of cancer treatment, such as pain, weight loss, and vomiting, evidences indicate that they might even help in suppressing tumor invasion.

Robert Ramer, Ph.D., and Burkhard Hinz, Ph.D., of the University of Rostock in Germany investigated whether and by what mechanism cannabinoids hold back tumor cell invasion.

It was found that Cannabinoids did suppress tumor cell invasion and stimulated TIMP-1 expression.

TIMP-1 is an inhibitor of a group of enzymes involved in tumor cell invasion.

“To our knowledge, this is the first report of TIMP-1-dependent anti-invasive effects of cannabinoids,” the authors said.

They added: “This signaling pathway may play an important role in the antimetastatic action of cannabinoids, whose potential therapeutic benefit in the treatment of highly invasive cancers should be addressed in clinical trials.”

The study was published in the Journal of the National Cancer Institute (ANI)”

“Inhibition of Cancer Cell Invasion by Cannabinoids via Increased Expression of Tissue Inhibitor of Matrix Metalloproteinases-1” http://jnci.oxfordjournals.org/content/100/1/59.long

http://www.topnews.in/health/cannabinoids-can-inhibit-tumor-cell-growth-highly-invasive-cancers-2380 

Active Chemicals in Cannabis Inhibits Prostate Cancer Cell Growth

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“According to researchers, active chemicals in cannabis inhibits prostate cancer cell growth…

cannabis

Professor Ines Diaz-Laviada, study author said: “Our research shows that there are areas on prostate cancer cells which can recognize and talk to chemicals found in cannabis called cannabinoids. These chemicals can stop the division and growth of prostate cancer cells and could become a target for new research into potential drugs to treat prostate cancer.””  http://www.elements4health.com/active-chemicals-in-cannabis-inhibits-prostate-cancer-cell-growth.html

“Inhibition of human tumour prostate PC-3 cell growth by cannabinoids R(+)-Methanandamide and JWH-015: Involvement of CB2″ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743360/

“Delta9-tetrahydrocannabinol induces apoptosis in human prostate PC-3 cells via a receptor-independent mechanism.” http://www.ncbi.nlm.nih.gov/pubmed/10570948

Marijuana Ingredient Inhibits VEGF Pathway Required For Brain Tumor Blood Vessels

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“Cannabinoids, the active ingredients in marijuana, restrict the sprouting of blood vessels to brain tumors by inhibiting the expression of genes needed for the production of vascular endothelial growth factor (VEGF).

“Blockade of the VEGF pathway constitutes one of the most promising antitumoral approaches currently available,” said Manuel Guzmán, professor of biochemistry and molecular biology, with the Complutense University in Madrid, Spain, and the study’s principal investigator.

“The present findings provide a novel pharmacological target for cannabinoid-based therapies.””

More: http://www.sciencedaily.com/releases/2004/08/040816085401.htm

“Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas.” http://cancerres.aacrjournals.org/content/64/16/5617.long

Inhibition of tumor angiogenesis by cannabinoids

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“Cannabinoids, the active components of marijuana and their derivatives, inhibit tumor growth in animal models… Because the generation of a new vascular supply (angiogenesis) is causally involved in the progression of the majority of solid tumors, the aim of this study was to test whether cannabinoids inhibit tumor angiogenesis.”

Figure 1.

“PRINCIPAL FINDINGS

1. Cannabinoid administration inhibits tumor angiogenesis

2. Cannabinoid administration inhibits vascular endothelial cell migration and survival

3. Cannabinoid administration inhibits tumor expression of proangiogenic factors and improves other markers of tumor malignancy

 

 …In the context of the renaissance in the study of the therapeutic effects of cannabinoids, our findings show that these compounds may be considered promising anti-tumoral agents as they inhibit tumor angiogenesis and growth in vivo with no significant side effects.

 This report provides a mechanistic basis for the anti-tumoral action of cannabinoids and a novel pharmacological target for cannabinoid-based anti-tumoral therapies…”

Full text:  http://www.fasebj.org/content/17/3/529.full

The use of cannabinoids in chronic pain.

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“We present the case of a 56-year-old man who developed chronic pain following the excision of a facial cancer that was poorly controlled despite multiple analgesic medications. Following the starting of nabilone (a synthetic cannabinoid) his pain control was greatly improved and this had a huge impact on his quality of life.

We also managed to significantly reduce his doses of opioid analgesia and ketamine.

We review the current literature regarding the medicinal use of cannabinoids, with an emphasis on chronic pain, in an attempt to clarify their role and how to select patients who may benefit from this treatment.”

http://www.ncbi.nlm.nih.gov/pubmed/23893276

From here to eternity – the secret of Pharaohs: Therapeutic potential of black cumin seeds and beyond

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“From here to eternity – the secret of Pharaohs: Therapeutic potential of black cumin seeds and beyond” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583426/

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“Anticarcinogenic effects of some Indian plant products.” http://www.ncbi.nlm.nih.gov/pubmed/1473788

“Plant products as protective agents against cancer.” http://www.ncbi.nlm.nih.gov/pubmed/2283166

“Potential of spice-derived phytochemicals for cancer prevention.” http://www.ncbi.nlm.nih.gov/pubmed/18612945

“Antimicrobial and chemopreventive properties of herbs and spices.” http://www.ncbi.nlm.nih.gov/pubmed/15180577

“Antioxidant activity and protecting health effects of common medicinal plants.” http://www.ncbi.nlm.nih.gov/pubmed/23034115

“Chemopreventive effects of Cuminum cyminum in chemically induced forestomach and uterine cervix tumors in murine model systems.” http://www.ncbi.nlm.nih.gov/pubmed/15087270

“Cancer cell signaling pathways targeted by spice-derived nutraceuticals.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3645308/

“Modulation of apoptosis in human hepatocellular carcinoma (HepG2 cells) by a standardized herbal decoction of Nigella sativa seeds, Hemidesmus indicus roots and Smilax glabra rhizomes with anti- hepatocarcinogenic effects.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364896/

“A long-term investigation of the anti-hepatocarcinogenic potential of an indigenous medicine comprised of Nigella sativa, Hemidesmus indicus and Smilax glabra” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1475831/

“[Anti-metastasis effect of thymoquinone on human pancreatic cancer]… thymoquinone (TQ), a component derived from the medicinal spice Nigella sativa (also called black cumin)” http://www.ncbi.nlm.nih.gov/pubmed/22007514

“Thymoquinone suppresses metastasis of melanoma cells by inhibition of NLRP3 inflammasome… our results indicate that thymoquinone can be a potential immunotherapeutic agent not only as an adjuvant therapy for melanoma, but also, in the control and prevention of metastatic melanoma.” http://www.ncbi.nlm.nih.gov/pubmed/23583630

“Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742606/

“Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism.” http://www.ncbi.nlm.nih.gov/pubmed/15375533

“Structure-Activity Studies on Therapeutic Potential of Thymoquinone Analogs in Pancreatic Cancer” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093961/

“Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and ERK signaling pathways” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2587125/

“Thymoquinone and cisplatin as a therapeutic combination in lung cancer: In vitro and in vivo” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909169/

“Comparison of potential chemotherapeutic agents, 5-fluoruracil, green tea, and thymoquinone on colon cancer cells.”  http://www.ncbi.nlm.nih.gov/pubmed/16817633

“Thymoquinone from Nigella sativa was more potent than cisplatin in eliminating of SiHa cells via apoptosis with down-regulation of Bcl-2 protein.” http://www.ncbi.nlm.nih.gov/pubmed/21609759

“Thymoquinone: potential cure for inflammatory disorders and cancer.” http://www.ncbi.nlm.nih.gov/pubmed/22005518

“Thymoquinone suppresses growth and induces apoptosis via generation of reactive oxygen species in primary effusion lymphoma.” http://www.ncbi.nlm.nih.gov/pubmed/21215312

“Anti-cancer effects of thymoquinone in mouse neuroblastoma (Neuro-2a) cells through caspase-3 activation with down-regulation of XIAP.” http://www.ncbi.nlm.nih.gov/pubmed/22732633

“Anticancer activity of thymoquinone in breast cancer cells: possible involvement of PPAR-γ pathway.” http://www.ncbi.nlm.nih.gov/pubmed/21679698

“Antineoplastic and apoptotic potential of traditional medicines thymoquinone and diosgenin in squamous cell carcinoma.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471895/

“Antineoplastic effects of bee honey and Nigella sativa on hepatocellular carcinoma cells.” http://www.ncbi.nlm.nih.gov/pubmed/21147814

“Antitumor and anti-angiogenesis effects of thymoquinone on osteosarcoma through the NF-κB pathway.” http://www.ncbi.nlm.nih.gov/pubmed/23232982

“Antiproliferative properties of methanolic extract of Nigella sativa against the MDA-MB-231 cancer cell line.” http://www.ncbi.nlm.nih.gov/pubmed/23317266

“Methanolic extract of Nigella sativa seed inhibits SiHa human cervical cancer cell proliferation through apoptosis… could potentially be an alternative source of medicine for cervical cancer therapy.”  http://www.ncbi.nlm.nih.gov/pubmed/23513732

“Plant crude extracts could be the solution: extracts showing in vivo antitumorigenic activity.” http://www.ncbi.nlm.nih.gov/pubmed/18390447

“Chemopreventive potential of volatile oil from black cumin (Nigella sativa L.) seeds against rat colon carcinogenesis.” http://www.ncbi.nlm.nih.gov/pubmed/12881014

“Cancer chemopreventive potential of volatile oil from black cumin seeds, Nigella sativa L., in a rat multi-organ carcinogenesis bioassay.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436209/

“Effect of Nigella sativa (N. sativa L.) and oxidative stress on the survival pattern of MCF-7 breast cancer cells.” http://www.ncbi.nlm.nih.gov/pubmed/12724920

“The in vitro anti-tumor activity of some crude and purified components of blackseed, Nigella sativa L.” http://www.ncbi.nlm.nih.gov/pubmed/9673365

“Antitumour principles from Nigella sativa seeds.” http://www.ncbi.nlm.nih.gov/pubmed/1555206

“Anti-tumor properties of blackseed (Nigella sativa L.) extracts.” http://www.ncbi.nlm.nih.gov/pubmed/17581684

“Anticancer activity of Nigella sativa (black seed) – a review.” http://www.ncbi.nlm.nih.gov/pubmed/22083982

“Anticancer activities of Nigella sativa (black cumin).” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252704/

“ANTI-CANCER ACTIVITY OF NIGELLA SATIVA” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3336718/

Curing With Curcumin – News

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“Chemical in Tumeric, Popular in Curries, May Cut Colon Cancer”  http://www.foxnews.com/story/2006/08/02/chemical-in-tumeric-popular-in-curries-may-cut-colon-cancer/

“Curry may help in fight against bowel cancer, study finds” http://www.foxnews.com/health/2012/05/08/curry-may-help-in-fight-against-bowel-cancer-study-finds/

 “Researchers Uncover Why Turmeric Helps Heal” http://abcnews.go.com/Health/Healthday/story?id=7769316&page=1

“Healing powers of turmeric uncovered” http://abclocal.go.com/kabc/story?id=6854704

 “Curry spice used to fight bowel cancer” http://www.abc.net.au/news/2012-05-08/curry-may-fight-bowel-cancer/3997590

“Turmeric inhibits cancer’s spread in mice” http://www.abc.net.au/news/2005-06-10/turmeric-inhibits-cancers-spread-in-mice/1589900

“The Healing Power Of Curry?” http://www.cbsnews.com/video/watch/?id=2681428n

“Curry May Cut Down Colon Cancer” http://www.cbsnews.com/2100-500368_162-1860248.html

“Seasonings That Help Your Health” http://www.cbsnews.com/2100-500165_162-799082.html

“Curry chemical’s ability to fight cancer put to the test” http://www.bbc.co.uk/news/health-17959521

“Curry spice ‘kills cancer cells'” http://news.bbc.co.uk/2/hi/health/8328377.stm

“Turmeric ‘Kills Cancer Cells'” http://www.huffingtonpost.com/2009/10/28/turmeric-kills-cancer-cel_n_336850.html

“Turmeric component kills cancer cells.” http://www.thefreelibrary.com/Turmeric+component+kills+cancer+cells.-a0123580388

“Scientists say curry compound kills cancer cells” http://www.abs-cbnnews.com/technology/10/28/09/scientists-say-curry-compound-kills-cancer-cells 
“Primary component in turmeric kicks off cancer-killing mechanisms in human saliva” http://medicalxpress.com/news/2011-09-primary-component-turmeric-cancer-killing-mechanisms.html

“Curcumin halts spread of breast cancer in mice – Early study shows spice stunts deadly spread to lungs” http://www.medicalnewstoday.com/releases/32147.php 

“How Curcumin Helps Fight Cancer” http://www.medicalnewstoday.com/releases/72129.php

“Curcumin Inhibits Prostate Cancer Metastases” http://www.medicalnewstoday.com/articles/251461.php

“Cancer Doctor Explains How Cooking with Turmeric Leads to Amazing Health Benefits” http://naturalsociety.com/cancer-doctor-explains-how-cooking-turmeric-health-benefits/

“Curry Spice Kills Cancer Cells” http://www.newser.com/story/72704/curry-spice-kills-cancer-cells.html

“Scientists say curry compound kills cancer cells” http://www.reuters.com/article/2009/10/28/us-cancer-curry-idUSTRE59R1E020091028

“Curcumin and melanoma. Can a spice help fight cancer?” http://health.usnews.com/usnews/health/briefs/cancer/hb050711a.htm

“Curry Spice May Fight Skin Cancer. Ingredient in Curry May Kill Melanoma Cells” http://www.webmd.com/cancer/news/20050711/curry-spice-fight-skin-cancer

“Curry compound could fight cancer; Curcumin may kill bowel cancer cells” http://www.nydailynews.com/life-style/health/curry-india-holy-powder-subject-cancer-fighting-proven-spice-curcumin-kill-bowel-cancer-cells-article-1.1074477

“Curcumin vs. cancer: The scientific evidence continues to flow in” http://www.naturalnews.com/039304_curcumin_cancer_scientific_evidence.html

“Curcumin and black pepper combine to stop breast cancer tumor cells” http://www.naturalnews.com/028763_cancer_tumors_curcumin.html

“Groundbreaking study: Aronia, curcumin extracts effectively kill brain cancer cell line” http://www.naturalnews.com/037476_aronia_curcumin_brain_cancer.html

“Curcumin slays cancer cells in their tracks” http://www.naturalnews.com/037879_curcumin_cancer_cells_turmeric.html

“Primary Component in Curry Spice Kicks Off Cancer-Killing Mechanisms in Human Saliva” http://www.sciencedaily.com/releases/2011/09/110913092430.htm

“Study: Chewing curcumin activates cancer-killing mechanisms” http://www.digitaljournal.com/article/311514

“Curry compound kills cancer cells” http://www.health24.com/Medical/Cancer/News/Curry-compound-kills-cancer-cells-20120721

 

Anti-cancer effects of curcumin (CUR) and tetrahydrocurcumin (THC) – Science

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Curry Powder.jpg
 

“Anticancer potential of curcumin: preclinical and clinical studies.” http://www.ncbi.nlm.nih.gov/pubmed/12680238

“Tetrahydrocurcumin is more effective than curcumin in preventing… colon carcinogenesis. Tetrahydrocurcumin (THC), a major metabolite of curcumin (CUR), has been demonstrated to be anti-cancerogenic and anti-angiogenic…these results demonstrated for the first time the in vivo chemopreventive efficacy and molecular mechanisms of dietary THC…”  http://www.ncbi.nlm.nih.gov/pubmed/21887819

“Tetrahydrocurcumin inhibits HT1080 cell migration and invasion via downregulation of MMPs and uPA.” http://www.ncbi.nlm.nih.gov/pubmed/18565284

“Plant-derived anticancer agents – curcumin in cancer prevention and treatment.”  http://www.ncbi.nlm.nih.gov/pubmed/23700916

“Anti-cancer and anti-angiogenic effects of curcumin and tetrahydrocurcumin on implanted hepatocellular carcinoma in nude mice” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701520/

“Mechanisms of cancer chemoprevention by curcumin.” http://www.ncbi.nlm.nih.gov/pubmed/11370761 

“Tetrahydrocurcumin, a major metabolite of curcumin, induced autophagic cell death through coordinative modulation of PI3K/Akt-mTOR and MAPK signaling pathways in human leukemia HL-60 cells.” http://www.ncbi.nlm.nih.gov/pubmed/21928294

 “Synergistic anticancer activity of curcumin and catechin: an in vitro study using human cancer cell lines.” http://www.ncbi.nlm.nih.gov/pubmed/21780253 

“Synergistic anticancer effects of curcumin and resveratrol in Hepa1-6 hepatocellular carcinoma cells.” http://www.ncbi.nlm.nih.gov/pubmed/23446753

“Curcumin enhances the anticancer effects of trichostatin a in breast cancer cells.” http://www.ncbi.nlm.nih.gov/pubmed/22290509

 “Curcumin polymers as anticancer conjugates.” http://www.ncbi.nlm.nih.gov/pubmed/20591475

“Curcumin Potentiates The Ability of Sunitinib to Eliminate the VHL-lacking Renal Cancer Cells 786-O: Rapid Inhibition of Rb Phosphorylation as a Preamble to Cyclin D1 Inhibition.” http://www.ncbi.nlm.nih.gov/pubmed/23848205

 “RL66 a second-generation curcumin analog has potent in vivo and in vitro anticancer activity in ER‑negative breast cancer models.” http://www.ncbi.nlm.nih.gov/pubmed/22971638

“ApoE3 mediated polymeric nanoparticles containing curcumin: apoptosis induced in vitro anticancer activity against neuroblastoma cells.” http://www.ncbi.nlm.nih.gov/pubmed/22890189

 “Inclusion complex of novel curcumin analogue CDF and β-cyclodextrin (1:2) and its enhanced in vivo anticancer activity against pancreatic cancer.” http://www.ncbi.nlm.nih.gov/pubmed/22322899

“Water-soluble antioxidants improve the antioxidant and anticancer activity of low concentrations of curcumin in human leukemia cells.” http://www.ncbi.nlm.nih.gov/pubmed/15700780

“Superior anticancer efficacy of curcumin-loaded nanoparticles against lung cancer.” http://www.ncbi.nlm.nih.gov/pubmed/23786839

“Dose-escalation and pharmacokinetic study of nanoparticle curcumin, a potential anticancer agent with improved bioavailability, in healthy human volunteers.” http://www.ncbi.nlm.nih.gov/pubmed/21603867

“Apigenin shows synergistic anticancer activity with curcumin by binding at different sites of tubulin.” http://www.ncbi.nlm.nih.gov/pubmed/23485682

 “Anticancer and carcinogenic properties of curcumin: considerations for its clinical development as a cancer chemopreventive and chemotherapeutic agent.” http://www.ncbi.nlm.nih.gov/pubmed/18496811

“Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: Identification of novel components of turmeric.” http://www.ncbi.nlm.nih.gov/pubmed/23847105

“Perspectives on new synthetic curcumin analogs and their potential anticancer properties.” http://www.ncbi.nlm.nih.gov/pubmed/23116312

“Synthesis and evaluation of curcumin-related compounds for anticancer activity.” http://www.ncbi.nlm.nih.gov/pubmed/22551677

 “Curcumin and its analogues: potential anticancer agents.” http://www.ncbi.nlm.nih.gov/pubmed/20027668

“Safe and targeted anticancer therapy for ovarian cancer using a novel class of curcumin analogs.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665575/

“Highly active anticancer curcumin analogues.” http://www.ncbi.nlm.nih.gov/pubmed/17569206 

Kurkumina

Health Benefits of Cannabis Tea

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Health Benefits of Cannabis Tea 

 

“Reduces Chronic Pain

Reduces Anxiety

Reduces Nausea

May Treat Autoimmune Diseases”

“Marijuana-Infused Tea… Mom always said a cup of tea at night makes it easier to sleep.. Kevin Reed, of The Green Cross medical marijuana dispensary in San Francisco, advises patients to add a little milk after brewing to get the full effect of the cannabis.”  http://www.cbsnews.com/2300-204_162-10004358-12.html

 

“Cannabis Tea… Other names: Pot Tea, Weed Tea…Translations: Kaņepes Tēja, Kanapių arbata, Ceai de canabis, Kanabis Tea, Cần sa trà, Cannabis urządzenia, कैनबिस चाय, Chá de Cannabis, Каннабис чай, Η κάνναβη Τσάι, القنب الشاي, 대마초 차, Cannabis Čaj, Cannabis Teh, 大麻茶, Cannabis para preparar té, Cannabis Čaj, קנאביס תה, Канабис чај, 大麻コーヒー, Cannabis Te, Cannabis per a preparar te, Каннабіс чай, Kannabis Tea, Канабис чай”     http://www.foodista.com/food/3HJ8KNK6/cannabis-tea#

“Cannabis tea revisited: a systematic evaluation of the cannabinoid composition of cannabis tea.”   http://www.ncbi.nlm.nih.gov/pubmed/17604926

25 Benefits to Drinking Green Tea