Cannabis-Derived Drug for Type 2 Enters Phase 2

“Cannabis-based drug for type 2s on the way?”

 
“A British drug company is looking to medical marijuana- or at least a derivative of it-to help treat a variety of different diseases, including type 2 diabetes.

The company, GW Pharma, is in the process of creating a collection of cannabinoid-based drugs, including one that takes aim at diabetes. The first of this type of drug the company has produced is Sativex, a nasal spray used to treat spasms associated with multiple sclerosis. Sativex has been okayed in eight countries, and is currently awaiting FDA approval in the United States.

The diabetes drug, GWP4204, is currently in its second phase of testing after a small but successful double-blind study. That study featured 62 type 2 patients who received various levels of the oral-administered drug or a placebo.”

More: http://diabeteshealth.com/read/2013/07/20/7933/cannabis-derived-drug-for-type-2-enters-phase-2–

Cannabis Kills Cancer Cells

“Marijuana also found to prevent pain associated with chemotherapy”

Cannabis Kills Cancer Cells

“Studies in Spain have shown findings that Tetrahydrocannabinol (THC), the active ingredient found in marijuana, can induce the death of brain cancer cells, according to scientist Guillermo Velasco and his research team from the School of Biology at Complutense University in Madrid.

In a laboratory study where mice were “engineered” to carry three varying kinds of human cancer tumor grafts, THC was introduced into the brain, triggering a self-digestion development on a cellular level, known as “autophagy.” Within this process, the research team managed to isolate the particular activation route from which this process evolved.

The research team was also conducting clinical trials in concert, on two consenting brain cancer patients, said to be suffering from a rapidly aggressive form of cancer, known as “recurrent glioblastoma multiforme.”

The team, using electron microscopes to analyze brain tissue extracted before and after the 26 to 30-day regime, found that the THC had eradicated cancer cells, leaving the healthy cells undamaged.

The findings can now lend themselves to future design in newer cancer therapies, using the concept of autophagy activation.”

More: http://guardianlv.com/2013/08/cannabis-kills-cancer-cells/

Cannabis Can Prevent Cancer Caused By Cigarette Use, According To New Study

tobacco cigarettes marijuana cannabis

“A new study published by the journal J-Stage, and funded by the Ministry of Education, Culture, Sports, Science and Technology of Japan, has found that cannabinoids – whether THC, CBD or CBDV – were effective at blocking a certain enzyme which is known to cause cancer, and is produced in large amount when cigarettes are consumed.”

“These results suggest that the pentylresorcinol structure in CBD may have structurally important roles in direct CYP1A1 inhibition, although the whole structure of CBD is required for overall inhibition”, according to researchers.

CYP1A1 is an enzyme which isn’t dangerous at low-levels, but is produced in large quantities when someone smokes cigarettes; at large doses, the enzyme has been linked to cancer.

Researchers state that; “Accordingly, CBD and its related compounds, which are potent inhibitors of CYP1A1 activity, would be useful as a lead compound in anticancer chemotherapy.””

http://www.theweedblog.com/cannabis-can-prevent-cancer-caused-by-cigarette-use-according-to-new-study/

“Marijuana Disrupts Cancer Pathway of Cigarettes: Study” http://www.truthonpot.com/2013/08/19/marijuana-disrupts-cancer-pathway-of-cigarettes-study/

Chemicals in marijuana block the activity of a cancer-causing enzyme present in cigarette smokers.
 
“Chemicals in marijuana can block the activity of a cancer-causing enzyme commonly found in cigarette smokers.”
 
 

“Cannabis Can Prevent Cancer Caused by Cigarette Use, According to New Study” http://thejointblog.com/cannabis-can-prevent-cancer-caused-by-cigarrette-use-according-to-new-study/ 

“Marijuana Can Prevent Millions of Tobacco Deaths” http://salem-news.com/articles/august122013/tobacco-marijuanapl.php

Marijuana Found to Kill Cancer Cells – The Marijuana and Cancer Relationship

“Thanks to the available findings of a 2006 study showing that cannabis actually reduces the number of cancer cells, medical marijuana users can now feel even better about the widely abolished pain relief ingredient found in the plant. The relationship between marijuana and cancer has always been up for debate, but with the use of a specially crafted oil made from the buds of the Cannabis Sativa plant, scientists confirmed that the plant’s primary psychoactive chemical tetrahydrocannabinol (THC) destroys any and all malignant cancer cell growths in several patients. Details on the marijuana and cancer prevention connection aren’t exactly known, but further, more extensive testing will reveal exactly what may be causing this seemingly miracle cure.”

More: http://www.realnews24.com/marijuana-found-to-kill-cancer-cells-the-marijuana-and-cancer-relationship/

Active Ingredient in Marijuana Kills Brain Cancer Cells

“New research out of Spain suggests that THC — the active ingredient in marijuana — appears to prompt the death of brain cancer cells.”

 
“The finding is based on work with mice designed to carry human cancer tumors, as well as from an analysis of THC’s impact on tumor cells extracted from two patients coping with a highly aggressive form of brain cancer.”
 

THC is anticarcinogenic: marijuana may be cancer cure!

“Toxicology and Carcinogenesis Studies of 1-Trans-[Delta.sup.9]-Tetrahydrocannabinol

Summation of above:

“Thus, in our studies, rats and mice that received THC for 2 years exhibited body weight reductions, enhanced survival rates, and decreased tumor incidences in several sites, mainly organs under hormonal control. These earlier experimental carcinogenesis results on THC clearly lend further validity to the notion that cannabinoids may indeed be anticarcinogenic.””

 link
http://www.thefreelibrary.com/Antitumor+Effects+of+THC-a06814…

http://www.sodahead.com/united-states/thc-is-anticarcinogenic-marijuana-may-be-cancer-cure/question-1031413/?link=ibaf&q=THC+anti-carcinogenic+news

Curing Cancer with Cannabis

“Repeal Archaic Anti-Marijuana Laws”

cannabis
“Although cannabis has been used in medical treatment for thousands of years in China and India, it became illegal in most of the western world in the first half of the twentieth century. This was thanks to an early corporate conspiracy involving DuPont, William Randolph Hearst, the Mellon Bank and Secretary of the Treasury Andrew Mellon. The major problem with hemp was its immense versatility. Most paper and nearly all plastics were made of hemp fiber, while hemp oil was a major fuel. Dupont was trying to promote their own petroleum-based plastic, Hearst his wood pulp paper factories, and Mellon his friends at Standard Oil. See The Politics of Hemp.

Recent research, mainly out of Spain and Italy (such research is  illegal in the US), reveals that treatment with a cannabis metabolite cannobidiol (CBD) has a marked effect on immune function and is useful in the treatment of breast, bowel and other metastatic cancers, diabetes, epilepsy, glaucoma, high blood pressure, chronic pain and a host of other medical conditions…

Below is a link to a groundbreaking lecture on the medical benefits of cannabis by University of California-San Francisco oncologist/AIDS specialist Donald Abrams, MD. Abrams contends that smoking cannabis actually reduces your chances of lung cancer, owing to its anti-inflammatory and immune effects.

More: http://open.salon.com/blog/stuartbramhall/2013/08/30/curing_cancer_with_cannabis

Texas A&M Pharmacy Researcher Fights Cancer, Pain With New Cannabinoid Receptor Drug

DrDaiLu

“Dr. Lu has been working to find new types of chemotherapeutic drugs that both kill pancreatic cancer and suppress the cancer pain at the same time by targeting a special G-protein coupled receptor that belongs to the biological system responsible for the effects of Tetrahydrocannabinol (THC), a compound derived from some varieties of cannabis (hemp) or made synthetically, that is the primary psychoactive agent in marijuana and hashish.

 Dr. Lu says pancreatic cancer cells have more type 2 cannabinoid receptors than do healthy cells.

 Consequently, drug molecules that selectively activate this receptor can induce cancer cell death without affecting normal pancreatic cells, noting that when given to mice with pancreatic tumors, the molecule prevented tumor growth and suppressed the spread of cancer to healthy organs.

 Meanwhile, this class of compounds also generates painkillers comparable to morphine’s pain killing effect…”

More: http://www.bionews-tx.com/news/2013/08/20/texas-am-pharmacy-researcher-fights-cancer-pain-with-new-cannabinoid-receptor-drug/

Dear Stoner: Can marijuana cure cancer?

“Yes, some parts of the cannabis plant have been shown to kill cancer cells in certain cases.” 

“Even if you don’t believe in any of that “hippie medicine” stuff, there’s been some actual scientific research done on cannabis and cancer, and a lot of it is promising. Spend a half-hour browsing around the National Center for Biotechnology Information website (ncbi.nlm.nih.gov) and you’ll find numerous studies on how various cannabinoids have been shown to slow or even kill tumor growth in everything from breast cancer to prostate cancer to skin cancer, thanks to our body’s natural endocannabinoids system.”

More: http://www.westword.com/2013-08-22/news/can-marijuana-cure-cancer/full/

Cannabinoids may be a target for new strategies in cancer treatment

“Cannabis-like substances that are produced by the body have both therapeutic and harmful properties, besides their well-known intoxicating effects, and the body’s cannabinoid system may be a target for new strategies in cancer treatment…

Cannabinoids have moreover been shown to affect the fate of cells. Cannabinoids protect some brain cells, whereas cells in certain types of brain tumors, such as glioma, are stimulated to commit controlled cell suicide (apoptosis)…

In summary, the findings of Sofia Gustafsson’s studies show that cannabinoids can be toxic for cancer cells… These findings are important for our knowledge both of the potential of the cannabinoid system as a target system for new strategies in cancer treatment…”

More: http://www.news-medical.net/news/20120229/Cannabinoids-may-be-a-target-for-new-strategies-in-cancer-treatment.aspx