Tag Archives: plant

Synthetic and Patented Cannabinoids

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“Historically, laboratory synthesis of cannabinoids were often based on the structure of herbal cannabinoids, and a large number of analogs have been produced and tested, especially in a group led by Roger Adams as early as 1941 and later in a group led by Raphael Mechoulam.

Newer compounds are no longer related to natural cannabinoids or are based on the structure of the endogenous cannabinoids.

Synthetic cannabinoids are particularly useful in experiments to determine the relationship between the structure and activity of cannabinoid compounds, by making systematic, incremental modifications of cannabinoid molecules.

Medications containing natural or synthetic cannabinoids or cannabinoid analogs:

  • Dronabinol (Marinol), is Δ9-tetrahydrocannabinol (THC), used as an appetite stimulant, anti-emetic, and analgesic
  • Nabilone (Cesamet), a synthetic cannabinoid and an analog of Marinol. It is Schedule II unlike Marinol, which is Schedule III
  • Sativex, a cannabinoid extract oral spray containing THC, CBD, and other cannabinoids used for neuropathic pain and spasticity in Canada and Spain. Sativex develops whole-plant cannabinoid medicines
  • Rimonabant (SR141716), a selective cannabinoid (CB1) receptor antagonist used as an anti-obesity drug under the proprietary name Acomplia. It is also used for smoking cessation

Other notable synthetic cannabinoids include:

  • CP-55940, produced in 1974, this synthetic cannabinoid receptor agonist is many times more potent than THC
  • Dimethylheptylpyran
  • HU-210, about 100 times as potent as THC
  • HU-331 a potential anti-cancer drug derived from cannabidiol that specifically inhibits topoisomerase II.
  • SR144528, a CB2 receptor antagonists
  • WIN 55, a potent cannabinoid receptor agonist
  • JWH-133, a potent selective CB2 receptor agonist
  • Levonantradol (Nantrodolum), an anti-emetic and analgesic but not currently in use in medicine”

http://www.news-medical.net/health/Synthetic-and-Patented-Cannabinoids.aspx

Cannabinoids – What are Cannabinoids?

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“Cannabinoids are a group of terpenophenolic compounds present in Cannabis (”Cannabis sativa”) and occur naturally in the nervous and immune systems of animals.

The broader definition of cannabinoids refers to a group of substances that are structurally related to tetrahydrocannabinol (THC) or that bind to cannabinoid receptors.

The chemical definition encompasses a variety of distinct chemical classes: the classical cannabinoids structurally related to THC, the nonclassical cannabinoids, the aminoalkylindoles, the eicosanoids related to the endocannabinoids, 1, quinolines and arylsulphonamides, and additional compounds that do not fall into these standard classes but bind to cannabinoid receptors.

The term ”cannabinoids” also refers to a unique group of secondary metabolites found in the cannabis plant, which are responsible for the plant’s peculiar pharmacological effects.

At the present time, there are three general types of cannabinoids: ”phytocannabinoids” occur uniquely in the cannabis plant; ”endogenous cannabinoids” are produced in the bodies of humans and other animals; and ”synthetic cannabinoids” are similar compounds produced in a laboratory.”

http://www.news-medical.net/health/Cannabinoids-What-are-Cannabinoids.aspx

MARIJUANA THC May Actually Help Protect YOUR BRAIN Against Injury, According to a New Study

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“Studies show that the THC in the plant has many therapeutic qualities…

Marijuana’s THC may be beneficial to humans.

Marijuana may actually help protect the brain against injury, a new study suggests.

Sarne said the study suggests that THC could be used to prevent brain injury or treat brain trauma.

Researchers believe that the THC treatment works by causing minute damage to the brain to build resistance and trigger protective measures in the face of much more severe injury.”

More: http://www.kpopstarz.com/articles/29846/20130602/marijuana-thc-may-help-protect-brain-from-injury.htm

Marijuana May Help Fight Brain Damage

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“Marijuana may actually help protect the brain against injury, a new study suggests.”

marijuana, cannabis, drug, addiction, weed

“While marijuana is most commonly known as a recreational drug, an increasingly number of studies show that the plant has many therapeutic qualities like relieving pain, insomnia, lack of appetite and other symptoms associated with conditions like cancer and PTSD.

Now a new study reveals that very low doses of Tetrahydrocannabinol (THC), the psychoactive ingredient in marijuana, may protect the brain from long-term cognitive damage in the wake of injury from hypoxia, seizures or toxic drugs.”

More: http://www.counselheal.com/articles/5586/20130530/marijuana-help-fight-brain-damage.htm

Is marijuana bad for you?

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“Hasn’t pot always been considered harmful?
Not at all. Marijuana, the dried form of the plant Cannabis sativa, was used as an herbal remedy for centuries in China, the Middle East, and Asia. William O’Shaughnessy, a physician for the East India Tea Company, brought it west in the 1830s as a treatment for rheumatism, tetanus, and rabies. It was commonly prescribed as a pain reliever in the U.S. until the 1930s, when its growing popularity caused such concern that the newly founded Federal Bureau of Narcotics reclassified it as a narcotic. The bureau soon launched a decidedly unscientific campaign claiming that marijuana use provoked insanity, homicidal tendencies, and uncontrollable lust. The marijuana user, the bureau asserted, “becomes a fiend with savage or ‘caveman’ tendencies. His sex desires are aroused, and some of the most horrible crimes result.””

Adolescents who smoked marijuana at least four times a week, lost an average of 8 IQ points between the ages of 13 and 38, according to a study from New Zealand.

“Was there any evidence for such claims?
None; in fact, the American Medical Association argued against marijuana prohibition in the 1930s, citing its therapeutic potential. But the bureau made its case that marijuana was “dangerous for the mind and the body,” and the federal government outlawed its use in 1937. It wasn’t until the 1970s that a campaign began to restore marijuana’s therapeutic reputation, and in 1996 California became the first state to legalize cannabis for medicinal purposes. Psychiatrist Tod Mikuriya, a founding father in the medical marijuana movement, claimed that cannabis has none of the adverse side effects of opiates. “In fact,” he said, “it really enhances both quality of life and rehabilitation.””

More: http://theweek.com/article/index/236671/is-marijuana-bad-for-you

Evidence: Cannabinoid Therapy Reduces Breast Cancer Tumors

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“Warning: Many alternative treatments are shams with zero proof. Most alternatives make claims that are not backed up by any evidence or hard empirical medical studies, are are not peer-reviewed. 
 
Peer review means your study and its claims will be vetted by a panel of the best doctors and other medical professionals in that field, for critical review. They will try to find fault in its methodology before publication and its recommendations for possible human treatment.
 
For any cannabis-based study strong enough to stand up to this critical review, and for it to be published in a major journal within such a field as cancer research, is incredible. That’s exactly how strong the evidence for cannabis medicine is starting to become.
 
Imagine that. This plant, this “great friend of humanity” which has helped us survive by giving early humans food, fuel, fiber and medicine, and who ancient healers wrote about in 6000 B.C., more than 8,000 years ago, is now coming back to prove itself and to help save us again.
 
And this time we are starting to find the evidence to back up the claims made for this plant over the centuries…”
 

Fighting Cancer: Another Study Reveals the Cannabis and Cancer Prevention Link

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“Does marijuana cause cancer? Revealing the link between cannabis and cancer yet again, researchers with the California Pacific Medical Center in San Francisco have released findings that further bolster cannabis as an anti-cancer solution.
The researchers have found a compound in the much-talked-about plant could “halt the spread” of many types of aggressive cancers, including breast cancer.

The Cannabis and Cancer Link

Cannabidiol is the compound, and while it fights cancer cells, it does not produce the high feelings commonly associated with cannabis. Instead, it seems to “switch off” the gene responsible for metastasizing breast cancer.

They reportedly found the compound doesn’t only stop the breast cancer cells from growing, but even causes them to return back to normal cells, cancer-free.”

More: http://naturalsociety.com/study-positive-cannabis-and-cancer-link/

Tommy Chong: Marijuana Legalization Boosts Economy, Weed Cures Prostate Cancer, According To Cheech’s Friend – But How? [REPORT]

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“Tommy Chong and his partner Richard “Cheech” Marin have built an entire career out of stoner comedy and marijuana-centric counterculture jokes, but now Tommy Chong is getting a little more serious about marijuana legalization and politics than he ever did before in Cheech & Chong’s 42-year entertainment career.”

Tommy Chong and Cheech Marin (Image: Reuters)

“Tommy Chong, 74, is a public advocate for the legalization of marijuana. He believes legalizing the drug on a federal level would bring about “numerous benefits,” including giving a lift to the U.S. economy – if the plant were to be taxed, of course.

In addition to the benefits to the economy, Tommy Chong believes in potential medical uses – medical uses that have been proven to the point where several states have legalized the drug. Almost 20 states have passed laws supporting the legalization of medical marijuana (with 12 states pending legislation!) Colorado and Washington have now totally legalized it.
 

Tommy Chong has personal ties to the medical usage of marijuana. Last June, Chong announced that he was suffering with stage one prostate cancer. However, he decided to forego traditional medicine and instead decided to overhaul his diet and lifestyle.

And now, Tommy Chong is cancer-free.”

More: http://www.idesigntimes.com/articles/5392/20130516/tommy-chong-marijuana-legalization-legalize-boosts-economy-celebrity-weed-post-ganja-cures-cancer-treats-treatment-prostate-cheech-friend-how-stoner-comedy-entertainment-movies-tv.htm

Marijuana mouth spray for cancer patients tough to abuse – NBC

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“The medical marijuana drug Sativex, which could be approved in the United States in the coming years as a treatment for pain relief, has little potential for abuse, experts say.

The British pharmaceutical company GW Pharmaceuticals is currently testing the drug, which is delivered as a mouth spray and called Sativex, in clinical trials. The company plans to seek U.S. Food and Drug Administration approval for the drug as a treatment for cancer pain when the trials are completed, likely sometime in 2014, a spokesperson for GW Pharmaceuticals told MyHealthNewsDaily.

The active ingredients in Sativex, known as cannabinoids, are derived from the cannabis plant. It is the first marijuana-based drug to be made by extracting the compounds from the plant, rather than synthesizing them. Two other drugs, Marinol and Cesamet, based on synthetic cannabinoids, were approved by the FDA in the 1980s.”

More: http://vitals.nbcnews.com/_news/2012/01/31/10280678-marijuana-mouth-spray-for-cancer-patients-tough-to-abuse?lite

What Is Marijuana? What Is Cannabis?

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“When talking about the drug, marijuana and cannabis both have the same meaning. When talking botanically – talking about the plant genus – we use the word Cannabis. Cannabis is a flowering plant genus that includes three acknowledged varieties:

  • Cannabis sativa
  • Cannabis indica
  • Cannabis ruderalis

The three types originally come from South and Central Asia.”

Bubba Kush

“Cannabis has been used for hundreds of years by humans, for fiber (hemp), seed oils, seed, medical treatment and recreationally.

This article focuses on cannabis’ medicinal and recreational aspects.”

Read more: http://www.medicalnewstoday.com/articles/246392.php