Cannabis Compound Could Help With Alzheimer’s Disease

cannabis 

“Neuroscientists suspect the main active ingredient in cannabis, called cannabidiol, could help prevent or reverse early stage brain damage and memory loss from Alzheimer’s disease, according to Australian newspaper the Sydney Morning Herald.

Tim Karl, a senior research fellow with Neuroscience Research Australia, said cannabidiol doesn’t have the same psychoactive effects as marijuana’s main component, THC (meaning it won’t get you high), but it does have anti-inflammatory, antioxidant and possible brain protective effects.

“Back in the day cannabis was used for medical purposes,” he said. “I’m talking 200 years, 100 years back, then at some point people discovered it had other effects and, as quite often happens in our society, people decided it was a bad drug.

But (cannabis isn’t) one compound, it is a mixture of 60 different compounds, and you just have to look at those different compounds because some of them might be good for you.””

Read more: http://www.blisstree.com/2013/02/06/sex-relationships/cannabis-brain/

The pharmacologic and clinical effects of medical cannabis.

“Cannabis, or marijuana, has been used for medicinal purposes for many years. Several types of cannabinoid medicines are available in the United States and Canada. Dronabinol (schedule III), nabilone (schedule II), and nabiximols (not U.S. Food and Drug Administration approved) are cannabis-derived pharmaceuticals.

Medical cannabis or medical marijuana, a leafy plant cultivated for the production of its leaves and flowering tops, is a schedule I drug, but patients obtain it through cannabis dispensaries and statewide programs. The effect that cannabinoid compounds have on the cannabinoid receptors (CB(1) and CB(2) ) found in the brain can create varying pharmacologic responses based on formulation and patient characteristics. The cannabinoid Δ(9) -tetrahydrocannabinol has been determined to have the primary psychoactive effects; the effects of several other key cannabinoid compounds have yet to be fully elucidated. Dronabinol and nabilone are indicated for the treatment of nausea and vomiting associated with cancer chemotherapy and of anorexia associated with weight loss in patients with acquired immune deficiency syndrome. However, pain and muscle spasms are the most common reasons that medical cannabis is being recommended.

Studies of medical cannabis show significant improvement in various types of pain and muscle spasticity. Reported adverse effects are typically not serious, with the most common being dizziness. Safety concerns regarding cannabis include the increased risk of developing schizophrenia with adolescent use, impairments in memory and cognition, accidental pediatric ingestions, and lack of safety packaging for medical cannabis formulations. This article will describe the pharmacology of cannabis, effects of various dosage formulations, therapeutics benefits and risks of cannabis for pain and muscle spasm, and safety concerns of medical cannabis use.”

http://www.ncbi.nlm.nih.gov/pubmed/23386598

Modulation of Cannabinoid Receptor Activation as a Neuroprotective Strategy for EAE and Stroke

“These results provide evidence that alteration of the activation patterns of the various cannabinoid receptors warrant consideration for future therapeutic strategies.

Interest in the medicinal use of Cannabis sativa (marijuana) has a long historical record, extending back thousands of years. In comparison to the extensive history for medicinal applications of marijuana, the existence of an “endocannabinoid system”, with important homeostatic and pathologic functions, has only recently gained appreciation. The endocannabinoid system consists of endogenously produced cannabinoids, their receptors, and the enzymes responsible for their synthesis and degradation…

Although used in ancient Greece, Rome, and China for therapeutic purposes, concern about the use of cannabinoids as a drug of abuse has dampened interest in developing the potential therapeutic benefits of these compounds. However, a better understanding of the biologic effects has led recently to an upsurge in interest for the development of therapeutic drugs through modification of the endocannabinoid system. An additional incentive was provided by the development of synthetic cannabinoid analogs and specific inhibitors of cannabinoid receptors. Several excellent reviews cover the therapeutic potential of cannabinoids….

The present review is focused on the effects of CB2 receptor activation in models of multiple sclerosis (experimental autoimmune encephalomyelitis) and stroke (middle cerebral occlusion/reperfusion).

In summary, selective CB2 receptor agonists and CB1 receptor antagonists have significant potential for neuroprotection in animal models of two devastating diseases that currently lack effective treatment options.”

Full text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855650/

Marijuana Oil Cured My Skin Cancer

“When his cancer came back for a fifth time, Michael McShane was desperate for treatment outside of traditional medicine.

The last time squamous cell carcinoma left lumpy tumors around his mouth, doctors cut it away and reconstructed his bottom lip by turning out a portion of its inner layer.

“You can only do most facial tricks once,” McShane, 51, said. “I needed another option.”

As a qualifying medical marijuana patient, he tried “Simpson oil” derived from cannabis plants by a Canadian named Rick Simpson. McShane bought some from an Oak Park dispensary that has since closed and puts a few drops every day on his face. Over the course of about 10 weeks, the tumors faded and then seemed to disappear.

His dermatologist, Ali Moiin, M.D., has said McShane isn’t cured but his cancer cells have decreased by about 60 percent.

“You still have some residual ones, but the size has definitely decreased,” Dr. Moiin told a WWJ reporter in late August, adding he thinks the results merit further scientific study.

Moiin didn’t return phone calls for an interview for this story. He isn’t the doctor who signed the physician certification form for McShane, who has another qualifying medical problem.

In all, since the Michigan Medical Marijuana Program started in April 2009, 2,215 of the state’s licensed physicians have certified that a patient suffers from one of the debilitating conditions identified in the act, and that the patient may find therapeutic and palliative relief from the medical use of marijuana. A total of 105,458 patient registry cards have been issued in that time period.

An estimated 55 doctors signed 70 percent of the certification forms, according to one review; most of the others aren’t talking about it publicly.

“I imagine it is a fairly sensitive issue because it is politically charged,” said Colin Ford, director of state and federal government relations for the Michigan State Medical Society.

Physicians are cautious because patient privacy is important, he said.

A forbidden cure?

Privacy isn’t as important to McShane as sharing what he considers his latest triumph over cancer without surgery, radiation, chemotherapy, reconstructive surgery and their side effects.

“The marijuana oil replaced all that and reduced the cancer to almost nothing,” he said. “My forehead and mouth were in bad shape in the spring. All of a sudden one morning it was there — a callous-like growth the size of a half dollar on my forehead. Skin cancer is my regular nemesis.”

McShane is one of a growing number of people extolling the healing properties of Simpson oil for everything from cancer, AIDS, Crohn’s disease, osteoporosis, arthritis, and diabetes to psoriasis, hemorrhoids and warts. They call it a “forbidden cure,” saying the oil that can be used topically or ingested isn’t given enough credit because it would cut into medical and pharmaceutical profits.”

By Catherine Kavanaugh
Daily Tribune Staff Writer

Video: http://www.youtube.com/watch?v=gr8RPjrsYSI

Cannabis Oil Cures Skin Cancer

“After yesterday’s post about how cannabis oil helped a two-year old recover from a brain tumor, we thought we’d share another medical marijuana success story involving canna-oil. Cannabis Science, Inc., a pioneering U.S. biotech company developing pharmaceutical cannabis products, demonstrated yet another occurrence of medical marijuana’s important role in curing cancer. The firm issued a press release that shows cannabis extracts appeared to be effective against a patient’s third incidence of basal cell carcinoma—the most common form of cancer with over 800,000 cases occurring annually in the US. 

The patient was an Australian woman from Queensland, the site of the highest rate of skin cancer in the world. She had numerous surgeries to remove previous lesions on her face including a basal cell carcinoma, but her lesions kept coming back. She then used cannabis oil topically as an alternative therapy – and it worked! Cannabis Science released a PDF that includes a series of photos that documents the disappearance of the lesion after ten days of self-administering topical cannabis extracts. They then received verbal confirmation from her physician that the sites of the former cancerous lesions are free of cancer cells. 

This is an amazing recovery from this patient, however the results aren’t atypical. Over 600 peer reviewed articles show that numerous cancer types (including lung, breast, prostate, glioma, thyroid, leukemia, lymphoma, basil cell carcinoma and melanoma) are killed by cannabinoids in tissue culture and animal studies. We know that medical marijuana  is effective against many diseases and ailments, including cancer—which is precisely why 15 states and Washington DC have passed medical marijuana laws allowing for the medical use of cannabis. It’s time that the rest of the country catches up. Let’s give patients the effective and safe medicine they need and deserve.”

https://www.marijuanadoctors.com/blog/marijuana-medical-conditions/Cannabis-Oil-Cures-Skin-Cancer

Skin Cancer Patient Says Oil From Medical Marijuana Is A Cure

“A Ferndale man claims he’s found a cure for his cancer and it’s now legal in Michigan.”

%name Skin Cancer Patient Says Oil From Medical Marijuana Is A Cure.

“WWJ’s Sandra McNeill spoke with Michael McShane who claims he’s been using a topical oil made from medical marijuana on the skin cancer on his forehead and in just over two months it’s nearly gone.

“I’ve got biopsies, chart notes, photographs … in about three weeks I’m going to go back  and really wrap this part of the case up,” said McShane. “It’s made the same way a lot of the fragrances and perfumes are made, and the oil is applied, in my case, directly to the skin, and within 10 weeks my cancer is gone.

“From a topical standpoint I don’t experience any euphoria,” said McShane.

McShane freely admits that he has smoked marijuana since he was in his teens, “It went from a party to a cure for cancer,” he said.”

Read more: http://detroit.cbslocal.com/2011/08/29/skin-cancer-patient-says-oil-from-medical-marijuana-is-a-cure/

Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors

“Cannabinoids inhibit skin tumor growth in vivo. Here we show that the CB1 and the CB2 receptor are expressed in normal skin and skin tumors of mice and humans. In cell culture experiments pharmacological activation of cannabinoid receptors induced the apoptotic death of tumorigenic epidermal cells, whereas the viability of nontransformed epidermal cells remained unaffected. Local administration of the mixed CB1/CB2 agonist WIN-55,212-2 or the selective CB2 agonist JWH-133 induced a considerable growth inhibition of malignant tumors generated by inoculation of epidermal tumor cells into nude mice. Cannabinoid-treated tumors showed an increased number of apoptotic cells.

 

Cannabinoids, the active components of Cannabis sativa linnaeus (marijuana)…

Marijuana and its derivatives have been used in medicine for many centuries, and currently there is a renaissance in the study of the therapeutic effects of cannabinoids… cannabinoids may be potential antitumoral agents owing to their ability to induce the regression of various types of tumors, including lung adenocarcinoma, glioma, and thyroid epithelioma in animal models.

This background prompted us to explore whether (a) the skin and skin tumors express cannabinoid receptors; (b) cannabinoid receptor activation exerts a growth-inhibiting action on skin tumors in vivo; and (c) inhibition of angiogenesis is implicated in the anti-tumoral effect of cannabinoids.

Our data show that (a) CB1 and CB2 receptors are present in the skin and skin tumors; (b) local cannabinoid receptor activation induces the regression of skin tumors in vivo; and (c) at least two mechanisms may be involved in this action: direct apoptosis of tumor cells and inhibition of tumor angiogenesis.

These results support a new therapeutic approach for the treatment of skin tumors.”

Full text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC151833/

A Population-based Case-Control Study of Marijuana Use and Head and Neck Squamous Cell Carcinoma

Logo of nihpa

“Marijuana (Cannabis sativa) contains more than 60 unique compounds known as cannabinoids. Cannabinoids, constituents of marijuana smoke, have been recognized to have potential antitumor properties. However, the epidemiological evidence addressing the relationship between marijuana use and the induction of head and neck cancer (HNSCC) is inconsistent and conflicting. An early epidemiological study reported that marijuana use was associated with an elevated risk for head and neck cancer.  However, more recent studies have failed to confirm the association of marijuana use with an increased head and neck cancer risk.

 In fact, many of these studies reported non-significant protective estimates of effect, consistent with a possible anticarcinogenic action of cannabinoids.

A recent epidemiologic review raised the need for additional, well conducted, large studies to clarify the nature of the association of marijuana use with the risk of cancer, especially head and neck cancer. In order to further elucidate the association between marijuana use and head neck cancer risk, we assessed marijuana use in detail in a population-based case-control study.

After adjusting for potential confounders (including smoking and alcohol drinking), 10 to 20 years of marijuana use was associated with a significantly reduced risk of HNSCC.

Our study suggests that moderate marijuana use is associated with reduced risk of HNSCC.”

How to Make a Glycerin-Based Medical Marijuana Tincture

" Making your own medical marijuana tincture is a fairly easy process. "

How to Make a Glycerin-Based Medical Marijuana Tincture

“Medical marijuana can come in many forms. A patient can choose his or her preferred method of consumption. Glycerin-based tinctures are very versatile and a great alternative to smoking, vaporizing, or strong-tasting alcohol-based tinctures.

A quality glycerin cannabis tincture can be mixed with any food or beverage and allows patients who need fast relief to place the tincture directly under their tongue. Not only does this method bring fast relief, it also allows patients to control their dosage in a similar manner to smoking their medicine. Although it takes a little time, making your own medical marijuana tincture is a fairly easy process.

Here’s what you will need to get started:
– A crock pot with a “low” and “warm” setting
– Cheesecloth
– Large bowl
– Latex gloves
– Wooden spoon
– 1 gallon of food-grade vegetable glycerin
– 1/4 -1/2 lb of medical marijuana or high quality trim material
– Glass storage container (not pictured)”

Read more: http://bigbudsmag.com/grow/how/article/how-make-glycerin-based-medical-marijuana-tincture-january-2013

Marijuana Compound May Beat Antipsychotics at Treating Schizophrenia

“A certain marijuana compound known as cannabidiol (CBD) can treat schizophrenia as well as antipsychotic drugs, with far fewer side effects, according to a preliminary clinical trial.”

Read more: http://psychcentral.com/news/2012/06/07/marijuana-compound-may-beat-antipsychotics-at-treating-schizophrenia/39803.html